HUMAN CHORIONIC GONADOTROPIN (hCG) FORMULATIONS FOR FACILITATING WEIGHT LOSS AND BODY CONTOURING
a technology of chorionic gonadotropin and formulation, which is applied in the direction of drug composition, peptide/protein ingredient, metabolic disorder, etc., can solve the problems of fatigue, surprising and unexpected weight loss and body contouring, and many patients typically complain about fatigue, so as to promote weight loss and/or body contouring, reduce body weight and/or contour the body
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[0095]In Applicant's studies, modification of the hCG formulation from the basic reconstituted hCG used in the Belluscio study, to include pH adjustment to about 7.0 and addition of an absorption enhancing agent (e.g., ethanol) have resulted in surprising and unexpected weight loss and body contouring.
[0096]The hCG formulation for sublingual administration in the WORKING EXAMPLE comprises 10,000 USP units in 10 ml of reconstituted lyophilized hCG, 1 ml sodium bicarbonate, 4 ml glycerin, and ethanol (total 5%)-adjusted to pH 7. In one group of patients (Low dose), doses of 0.125 ml of the above hCG formulation was administered sublingually twice a day (once in the morning, once in the evening) in combination with a VLCD daily diet (similar to that used by Belluscio) of between about 500 and about 700 calories comprising low or no calorie fluids, lean meats and fish and other proteins, vegetables and fruits, small portions of carbohydrates, artificial sweeteners, seasonings, and water...
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