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HUMAN CHORIONIC GONADOTROPIN (hCG) FORMULATIONS FOR FACILITATING WEIGHT LOSS AND BODY CONTOURING

a technology of chorionic gonadotropin and formulation, which is applied in the direction of drug composition, peptide/protein ingredient, metabolic disorder, etc., can solve the problems of fatigue, surprising and unexpected weight loss and body contouring, and many patients typically complain about fatigue, so as to promote weight loss and/or body contouring, reduce body weight and/or contour the body

Inactive Publication Date: 2009-07-16
RELEANA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The sublingual and transdermal hCG formulations provide effective weight loss and body contouring, are more convenient than injections, and are appealing to patients, achieving similar results to injections with improved patient compliance and safety.

Problems solved by technology

Also many patients typically complain about fatigue in the course of a VLCD.
In Applicant's studies, modification of the hCG formulation from the basic reconstituted hCG used in the Belluscio study, to include pH adjustment to about 7.0 and addition of an absorption enhancing agent (e.g., ethanol) have resulted in surprising and unexpected weight loss and body contouring.

Method used

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Examples

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Effect test

working example

[0095]In Applicant's studies, modification of the hCG formulation from the basic reconstituted hCG used in the Belluscio study, to include pH adjustment to about 7.0 and addition of an absorption enhancing agent (e.g., ethanol) have resulted in surprising and unexpected weight loss and body contouring.

[0096]The hCG formulation for sublingual administration in the WORKING EXAMPLE comprises 10,000 USP units in 10 ml of reconstituted lyophilized hCG, 1 ml sodium bicarbonate, 4 ml glycerin, and ethanol (total 5%)-adjusted to pH 7. In one group of patients (Low dose), doses of 0.125 ml of the above hCG formulation was administered sublingually twice a day (once in the morning, once in the evening) in combination with a VLCD daily diet (similar to that used by Belluscio) of between about 500 and about 700 calories comprising low or no calorie fluids, lean meats and fish and other proteins, vegetables and fruits, small portions of carbohydrates, artificial sweeteners, seasonings, and water...

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Abstract

The present invention relates to formulations of hCG for sublingual administration to mammals to facilitate weight loss and / or body contouring. Embodiments of the invention disclose administration of hCG formulations in combination with a low calorie diet and dietary supplements and, in some cases, with an exercise regime. Embodiments of this invention also disclose transdermal hCG formulations and hCG formulations for administration through other administration routes.

Description

RELATED APPLICATIONS[0001]This application is a divisional of application Ser. No. 11 / 496,554 filed on Jul. 31, 2006, which claims priority to and benefits from U.S. Provisional Patent Application No. 60 / 704,014, filed Jul. 29, 2005.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]This invention relates generally to formulations incorporating human chorionic gonadotropin for administration to mammals to facilitate weight loss and body contouring.[0004]2. Description of the Related Art[0005]hCG (human chorionic gonadotrophin) is a hormone that is naturally produced during pregnancy. hCG is a glycoprotein hormone normally secreted by trophoblastic cells of the placenta during pregnancy. It consists of two chains, called the alpha and beta subunits. It is believed that one of the functions of hCG in pregnancy is to provide a constant supply of fat to the fetus regardless of what or when the mother eats. And, in particular, hCG works to supply both mother and fetus with a...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/14A61P3/04
CPCA61K9/0056A61K9/006A61K38/24A61K31/7012A61K31/045A61P3/04
Inventor TUNTLAND, DEIRDRE S.
Owner RELEANA LLC
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