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Percutaneously Absorbable Preparation, Percutaneously Absorbable Preparation Holding Sheet, and Percutaneously Absorbable Preparation Holding Equipment

a technology of absorbable preparations and percutaneous administration, applied in the direction of drug compositions, immunological disorders, metabolism disorders, etc., can solve the problems of difficult absorption of macromolecular drugs such as insulin limited use of these percutaneous preparations, and difficult systemic therapy with drugs through the percutaneous route, etc., to achieve convenient administration, efficient percutaneous administration, and high efficiency

Inactive Publication Date: 2008-10-23
BIOSERENTACH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0062]By use of the percutaneously absorbable preparations embodying the present invention, even if the active substance is a percutaneously poorly absorbable drug, it is efficiently administered percutaneously into the body.
[0063]By use of the sheet-like carrier embodying the present invention, the percutaneously absorbable preparations are highly efficiently administered.
[0064]By use of the equipment embodying the invention, the needle-like or filamentous shape percutaneously absorbable preparations are easily administered with high accuracy.

Problems solved by technology

The use of these percutaneous preparations is usually limited to the local therapy of disease localized on the skin.
Because of the barrier function possessed by the skin, the systemic therapy with drugs through the percutaneous route is difficult due to the low systemic availability of locally applied drugs to the skin.
So far, the absorption of macromolecular drugs such as insulin through percutaneous route is difficult because of their low skin permeability and no percutaneous preparations have been developed up to now.

Method used

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  • Percutaneously Absorbable Preparation, Percutaneously Absorbable Preparation Holding Sheet, and Percutaneously Absorbable Preparation Holding Equipment
  • Percutaneously Absorbable Preparation, Percutaneously Absorbable Preparation Holding Sheet, and Percutaneously Absorbable Preparation Holding Equipment
  • Percutaneously Absorbable Preparation, Percutaneously Absorbable Preparation Holding Sheet, and Percutaneously Absorbable Preparation Holding Equipment

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0147]This example illustrates a percutaneously absorbable preparation having a needle-like and filamentous shape and containing interferon (active substance) held in a base consisting of human serum albumin.

[0148]About 0.2 mL of distilled water was added to 150 mg of human serum albumin (Sigma) to be dissolved. The solution was mixed well to give a base paste consisting of human serum albumin. To this base paste, μL of interferon alpha injection solution “Sumiferon” (Trademark, 6,000,000 units / mL, Sumitomo pharmaceuticals), corresponding to 60,000 IU, was added and well mixed so that interferon was held in the base paste. To the base paste holding interferon, a top of a glass stick of which diameter was about 3 mm was attached. Thereafter, the top was gradually pulled apart so that the base paste attaching to the top has a needle-like or filamentous shape. The needle-like or filamentous base paste was solidified by drying at low temperature to give a percutaneously absorbable prepa...

example 2

[0150]This example illustrates a percutaneously absorbable preparation having a needle-like and filamentous shape and containing interferon (active substance) held in a base consisting of bovine serum α-acid glycoprotein (AAG).

[0151]About 50 μL of distilled water was added to 50 mg of bovine AAG (Sigma) to be dissolved. The solution was mixed well and water was evaporated to give a base paste consisting of AAG. To this base paste, 10 μL of interferon alpha injection solution “Sumiferon” (Trademark, 6,000,000 units / mL, Sumitomo pharmaceuticals), corresponding to 60,000 IU, was added and well mixed so that interferon was held in the base paste. A Percutaneously absorbable preparation having a needle-like or filamentous shape was made with a glass stick in the same way as Example 1.

example 3

[0152]This example illustrates a percutaneously absorbable preparation having a needle-like and filamentous shape and containing FITC-labeled albumin (active substance) held in a base consisting of human serum albumin. FITC-labeled albumin was used as a model of vaccine.

[0153]FITC-labeled albumin was prepared by labeling human serum albumin with fluorescein isothiocyanate (FITC). On the other hand, about 0.2 mL of distilled water was added to 130 mg of human serum albumin (Sigma) to be dissolved. The solution was mixed well to give a base paste consisting of human serum albumin. To this base paste, 20 mg of FITC-labeled albumin was added and well mixed, so that FITC-labeled albumin was held in the base paste. To the base paste holding FITC-labeled albumin, a top of a polypropylene stick of which diameter was about 2 mm was attached. Thereafter, the top was gradually pulled apart so that the base paste attaching to the top has a needle-like or filamentous shape. The needle-like or fi...

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Abstract

Self-dissolving needle-like or filamentous shape percutaneously absorbable preparations, by which inherently poorly absorbable drugs into the body through the skin is efficiently administered. The preparations are made of at least one material selected from the group consisting of proteins, polysaccharides, polyvinyl alcohols, carboxyvinyl polymers and sodium polyacrylic acids. An active substance contained therein is released in a sustained-release fashion (1) by forming a water-insoluble layer on its surface, (2) by holding the active substance in porous materials, or (3) by imparting a long-acting characteristic to the active substance. The present invention also provides a sheet-like carrier for holding the preparations on at least one of the sides thereof, and a piece of equipment for holding the preparations so as to facilitate the administration of them.

Description

TECHNICAL FIELD[0001]The present invention relates to percutaneously absorbable preparations per se, a sheet-like carrier for holding the preparations, and a piece of equipment for holding the preparations. More particularly, it relates to (1) a self-dissolving percutaneously absorbable preparation having a slender, pointed shape adapted for insertion into the skin, this shape being hereinafter referred to as “needle-like or filamentous shape”, the preparations which include a base holding an active substance of proteins and polysaccharides etc., (2) a sheet-like carrier for holding the percutaneously absorbable preparations on at least one of the sides thereof, and (3) a piece of equipment for holding the preparations in a penetration hole formed in its main body. In this specification, the term “preparations” in plural means not only a product but also products, so as to distinguish from “preparation” in singular meaning the act of preparing.BACKGROUND ART[0002]As one of the nonin...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M31/00A61K47/32A61K47/42A61K47/36A61K47/38A61K38/02A61K31/715A61K48/00A61K39/00A61K38/28
CPCA61M37/0015A61M2037/0046A61M2037/0061A61K9/0021A61K9/7007A61K31/375A61K31/727A61K38/21A61K38/28A61P3/10A61P37/00A61P5/50A61K9/70A61K47/42
Inventor TAKADA, KANJI
Owner BIOSERENTACH
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