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Method for preparing a compressed wound dressing

a wound dressing and compressed technology, applied in the field of hemorrhage control wound dressings, can solve the problems of no low-cost wound dressings suitable for severe life-threatening bleeding, and achieve the effects of accelerating blood clot formation, and reducing the risk of bleeding

Inactive Publication Date: 2008-06-19
TRICOL BIOMEDICAL INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is a wound dressing that can control severe bleeding in the battlefield and in other life-threatening situations. It is made of a hydrophilic polymer that can adhere to the wound and form a seal, stopping bleeding and promoting clot formation. The dressing can also contain an active ingredient, such as calcium or thrombin, to further enhance its effectiveness. The dressing can be made in the form of a compressed sponge or a composite sponge with a wettable polymer matrix. It can be used in various situations where control of bleeding is critical.

Problems solved by technology

Presently there are no low cost wound dressings that are suitable for control of severe life-threatening bleeding.

Method used

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  • Method for preparing a compressed wound dressing
  • Method for preparing a compressed wound dressing
  • Method for preparing a compressed wound dressing

Examples

Experimental program
Comparison scheme
Effect test

example 1

Hemorrhage Control Testing

[0148]Table 1 provides a list of the main chitosan materials acquired for hemorrhage control testing. With the exception of the Gelfoam™+thrombin, and Surgicel™ controls for swine spleen experiments and the Johnson and Johnson 4″×4″ gauze control for use in swine aortic perforations, the dressing materials described here were all chitosan-based.

TABLE 1SourceProtosan (Norway)Carbomer(USA)Primex (Norway)GenisSample NameG213G113CL213CL1139012-75-4Chitoclear(Iceland)Batch Number511-583-01005-370-01607-783-02310-490-01VA-UY992BN 381TM 752TM 751SO11115-1Bio-SourceCrab & / orCrab & / orCrab & / orCrab & / orShrimpShrimpShrimpShrimpShrimpShrimpShrimpShrimpShrimpAppearanceFine whiteFine whiteFine whiteFine whiteYellowedFine off-Fine off-Fine off-Off-whitepowderpowderpowderpowderpowder +whitewhitewhiteflakespeckspowderpowderpowderViscosity cps1081213312NANA1091561216(1% soln)% Dry Matter93.090.390.893.9NANA97.797.693% Protein0.20.20.10.1NANA% Deacetylation868584879089939190L...

example 2

Preparation and Evaluation of Wound Dressing

[0152]Hemostatic wound dressings were prepared as follows:

a) Dry chitosan powder or flake with degree of deactylation above 85%, less than 26 ppm metallic component and greater than 90% dry solids content was made in a 2% aqueous solution (w / w) with about 2 or 1% acetic acid (w / w) at 40° C.

b) The solution of chitosan from a) above was degassed under reduced pressure at up to about 500 mTorr under agitation for at least 5 minutes and poured into a mold to a depth of 1.7 cm. Certain low-density, foam structures exhibited problems due to their ready dissolution in a bleeding field. These problems were generally avoided by thorough degassing of the solution.

c) The mould containing the degassed chitosan solution was frozen by cooling from room temperature to −45° C. A linear cooling ramp was used over a 90 minute period, and the temperature was maintained at −45° C. for at least another hour.

d) The frozen chitosan was then freeze dried using a ...

example 3

Hepatic Hemorrhage Control in Swine Liver Model

[0183]The US Army Science and Technology Objective (STO) A, Hemorrhage Control, was established in 2000 to advance the need for hemorrhage control on the battlefield. The general strategic objective of the STO can be summarized as the development of products and methods that will reduce the number of deaths due to hemorrhage in battlefield casualties. The requirements for hemorrhage control products and methods were stated thus:

[0184]They must be practicable for use by one or more of the following: self (wounded combatant), buddy (fellow non-medical soldier who aids the wounded soldier), combat lifesaver, combat medic, physician assistant, and battalion surgeon. They must be practicable for use in far forward field conditions including rugged terrain, limited visibility, and environmental extremes. Products and methods must not require external electrical sources. All devices must be man-portable and durable. It is expected that product...

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Abstract

An aqueous solution of polyacrylic acid is placed in a mold, frozen, and freeze-dried to form a sponge-like polyacrylic acid structure. The sponge-like polyacrylic acid structure is compressed by the application of heat and pressure to reduce the thickness and increase the density of the sponge-like polyacrylic acid structure to form a densified polyacrylic acid structure. The densified polyacrylic acid structure is preconditioned by heating to form a wound dressing. The wound dressing can be applied to control severe, life-threatening bleeding from a wound at a wound site of a person.

Description

RELATED APPLICATIONS[0001]This application is a divisional of co-pending U.S. patent application Ser. No. 10 / 743,051, filed 23 Dec. 2003, and entitled “Wound Dressing and Method for Controlling Severe, Life-Threatening Bleeding,” which is incorporated herein by reference.FIELD OF THE INVENTION[0002]This invention is directed to hemorrhage control wound dressings, and methods of using and producing such dressings. The subject wound dressing is constructed from a non-mammalian material for the control of severe bleeding. The wound dressing is formed of a biomaterial comprising chitosan and / or other hydrophilic polymers for controlling severe bleeding. The material may alternatively comprise polyacrylic acid or a combination of polyacrylic acid with other polymers. The kind of severe, life-threatening bleeding contemplated by this invention is of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional pressure to the wound. The wound...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F13/02B29C35/02A61F13/00A61F15/00A61F17/00A61L15/42
CPCA61F13/02A61F13/0276A61L15/425A61F2013/00472A61F17/00A61F13/0223A61F13/0226A61P17/02A61L15/00A61L15/10A61L15/12A61L15/14
Inventor CAMPBELL, TODD D.WIESMANN, WILLIAM P.MCCARTHY, SIMON J.
Owner TRICOL BIOMEDICAL INC
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