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Medicine composition for treating diabetes

A composition and diabetes technology, which is applied in the field of pharmaceutical compositions for treating diabetes and high-content salvianolic acid salts, can solve problems such as extensive preparations, difficulty in ensuring therapeutic effects, and unstable quality, and reduce Blood viscosity, treatment of diabetes and its complications, effect of lowering blood sugar

Inactive Publication Date: 2007-06-27
GREEN VALLEY GROUP CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been studies using Pueraria root and Salvia miltiorrhiza to treat diabetes and its complications. However, the current Chinese patent medicine preparations of Pueraria root and Salvia miltiorrhiza are extensive, the quality is unstable, and the therapeutic effect is difficult to guarantee. The existing preparations do not meet the modernization and internationalization of traditional Chinese medicine. requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Effect of total flavonoids of kudzu root and salvianolate on blood sugar in STZ rats

[0022] Take 60 rats, fast for 12 hours, and inject streptozotocin 50mg·kg rapidly into the tail vein -1 , Measure the blood glucose value after 72h. Choose a blood sugar level of 13mmol·L -1 Those above were randomly divided into three groups according to body weight. The model group and the treatment group were given Pueraria root and Danshen water decoction and Pueraria total flavonoids and salvianolate composition, 8 rats in each group, orally administered, qd, for 30 days in a row . A normal control group was also set up. After fasting for 12 hours, cut the tail of the rat to take blood, and measure blood glucose (BG) with the ONE TOUCH blood glucose meter; remove the eyeball of the rat to take blood, anticoagulate in vitro with heparin, take 50 μl of blood, and measure glycosylated hemoglobin (HbAlC ). The t-test before and after administration was performed in eac...

Embodiment 2

[0027] Embodiment 2, the influence of kudzu root extract on the hemodynamics of STZ rats

[0028] The animal grouping and experimental method were the same as in Example 1. Rat eyeballs were picked to get 4ml of blood, (in vitro anticoagulation with heparin, 20 / ml), and the following indicators were measured; (1) Whole blood viscosity (ηb). (2) Plasma viscosity (ηp). (3) Hematocrit (HCT). (4) Erythrocyte sedimentation rate (ESR). The results of variance analysis showed that among the administration group, the normal group and the model group, in addition to the erythrocyte sedimentation rate, the whole blood high shear viscosity [γ(1 / s, 10.00)], low shear viscosity [γ(1 / s, 120.00)], Plasma viscosity and hematocrit all have significant differences (P<0.05, P<0.01), indicating that the medicine of the present invention can improve blood rheology. Table 2 shows the effect of the Pueraria root extract of the present invention on the hemodynamics of STZ rats.

[0029] Table 2 ...

Embodiment 3

[0034] According to the active ingredient extraction method of the present invention, extract the total flavonoids of Pueraria lobata and the high-content salvianolate extracted from Radix Salviae Miltiorrhizae respectively, take 1 part of total flavonoids of Pueraria lobata and 0.1-9 parts by weight of salvianolate , add corresponding various auxiliary materials, after uniform mixing, make various pharmaceutically acceptable dosage forms according to the existing preparation technology.

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PUM

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Abstract

The present invention discloses a kind of diabetes treating medicine composition, which consists of flavone compound extracted from kudzu vine root and red sage polyphenolate extracted from red sage in certain ratio. Of the composition, the kudzu vine root extract contains kudzu vine root flavonid in 50-95 wt%, and the red sage extract contains magnesium red sage acetate in 50-95 wt% and polyphenolate approaching 100 wt%. The medicine composition has the synergistic effect of the components in treating diabetes and diabetes complications and may be used as the medicine for treating diabetes and diabetes complications. The present invention also provides the preparation process of kudzu vine root flavonid and red sage polyphenolate.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a pharmaceutical composition for treating diabetes, in particular to a pharmaceutical composition composed of total flavonoids of Pueraria radiata extracted from Pueraria lobata root and high-content salvianolate extracted from Salvia miltiorrhiza. Background technique [0002] According to WHO reports, in 1995 there were 125 million diabetic patients in the world. In the Asia-Pacific region, diabetes has become an endemic disease in many countries, especially those in newly industrialized countries. Epidemiological studies have shown that Micronesians, Polynesians, certain Melanesians, Asian Indians and Chinese immigrants, and Australian aborigines are high-risk ethnic groups for diabetes. Diabetes has become one of the major public health problems faced by both developing and developed countries. It is predicted that the number of people with diabetes worl...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/00A61P3/10
Inventor 刘梅英李廷钊孟庆国王茵毛士龙吴云鸣杨勇袁红徐丹
Owner GREEN VALLEY GROUP CO LTD
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