Antivirus Chinese medicinal formulation, preparation process, quality control method and application thereof

A traditional Chinese medicine preparation and antiviral technology, applied in antiviral agents, pharmaceutical formulations, pill delivery, etc., can solve the problems of Western medicine with large side effects, slow onset of effect, and large dosage of patients.

Inactive Publication Date: 2007-05-30
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many medicines for treating colds on the market, Western medicines generally have the problem of large side effects, while Chinese patent medicines are medicines that are used to treat diseases according to different causes and combined with TCM theory, such as wind-cold cold, wind-heat cold, etc. choose different drugs for treatment
Moreover, there are disadvantages such as dizziness, drowsiness, and weakness of limbs in Western medicine cold medicines currently on the market; while pure Chinese medicine cold medicines have disadvantages such as slow onset of action.
In order to achieve better prevention and control purposes, many inventors and pharmaceutical companies have done a lot of research, and also provided some excellent therapeutic products; such as: patent application number: 200410048399.7, named "An antiviral orally disintegrating tablet and Its preparation method” patent application, it is used for cold diseases and has a quick effect; but in-depth research found that the use of large prescriptions with many medicinal flavors, the composition of the preparation is complicated, and the patient takes a large amount of medicine. On this basis, the applicant used Scutellaria baicalensis, Epimedium, Houttuynia cordata and their extracts as the drug prescription, which can not only reduce the dosage of patients, but also remove some components with strong toxic and side effects in the extracts of medicinal materials by using a reasonable process , which improves the safety and quality controllability of the preparation, greatly improves the curative effect, and is more conducive to the molding of the preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1 of the present invention: Scutellaria baicalensis 50g Epimedium 25g Houttuynia cordata 25g

[0064] A, the preparation method of Scutellaria baicalensis extract is: Scutellaria baicalensis is pulverized, add 8 times of volume 70% ethanol and reflux extract 3 times, each time 1 hour, combine extract, filter, ethanol is reclaimed from filtrate under reduced pressure, measure relative when concentrating to 60 ℃ The concentration is 1.05~1.15, add 3 times the volume of water to dissolve, filter, the filtrate passes through the AB-8 macroporous resin column, wash with 6 times of water first, then desorb with 60% ethanol, collect the desorption liquid, recover ethanol under reduced pressure, concentrate The measured relative density at 60°C is 1.05-1.15, and vacuum-dried to obtain the Scutellaria baicalensis extract.

[0065] B. The preparation method of Epimedium extract is: Epimedium is cut into small sections of about 1 cm, added 10 times the volume of 70% eth...

Embodiment 2

[0068] Embodiment 2 of the present invention: Scutellaria baicalensis 50g Epimedium 25g Houttuynia cordata 25g

[0069] A, the preparation method of Scutellaria baicalensis extract is: Scutellaria baicalensis is pulverized, add 8 times of volume 70% ethanol and reflux extract 3 times, each time 1 hour, combine extract, filter, ethanol is reclaimed from filtrate under reduced pressure, measure relative when concentrating to 60 ℃ The density is 1.05~1.15, add 3 times volume of water to dissolve, filter, the filtrate passes through AB-8 macroporous resin column, wash with 6 times of water first, then desorb with 60% ethanol, collect the desorption liquid, recover ethanol under reduced pressure, concentrate The measured relative density at 60°C is 1.05-1.15, and vacuum-dried to obtain the Scutellaria baicalensis extract.

[0070] B. The preparation method of Epimedium extract is: Epimedium is cut into small sections of about 1 cm, added 10 times the volume of 70% ethanol to reflux...

Embodiment 3

[0073] Embodiment 3 of the present invention: Scutellaria baicalensis 40g Epimedium 60g

[0074] A, the preparation method of Scutellaria baicalensis extract is: Scutellaria baicalensis is pulverized, add 8 times of volume 70% ethanol and reflux extract 3 times, each time 1 hour, combine extract, filter, ethanol is reclaimed from filtrate under reduced pressure, measure relative when concentrating to 60 ℃ The density is 1.05~1.15, add 3 times volume of water to dissolve, filter, the filtrate passes through AB-8 macroporous resin column, wash with 6 times of water first, then desorb with 60% ethanol, collect the desorption liquid, recover ethanol under reduced pressure, concentrate The measured relative density at 60°C is 1.05-1.15, and vacuum-dried to obtain the Scutellaria baicalensis extract.

[0075]B. The preparation method of Epimedium extract is: Epimedium is cut into small sections of about 1 cm, added 10 times the volume of 70% ethanol to reflux and extracted 3 times, ...

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PUM

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Abstract

The invention discloses a compound Chinese medicinal preparation which comprises baikal skullcap root, barren wort and houttuynia cordata, and can be prepared into injections, capsules, tablets, dispersible tablets, sublingual tablets, granules, oral liquid preparations, drop pills and other pharmacologically allowable dose forms. The preparation has the advantages of definite curative effects, better stability, lower toxic and side effects, The preparation can be used for treating pneumonia, respiratory tract infection, influenza, avian Influenza, SARS, asthma, and low body immunity.

Description

technical field [0001] The invention relates to an antiviral traditional Chinese medicine preparation and its preparation method, quality control method and application, belonging to the technical field of traditional Chinese medicine. technical background [0002] A cold is an upper respiratory tract infection caused by a variety of viruses, commonly known as "cold", and is a common respiratory disease that can occur in all seasons. Viral influenza is upper respiratory tract infection, also referred to as upper flu, which is a common respiratory infectious disease caused by multiple viruses. Although there are many medicines for treating colds on the market, Western medicines generally have the problem of large side effects, while Chinese patent medicines are medicines that are used to treat diseases according to different causes and combined with TCM theory, such as wind-cold cold, wind-heat cold, etc. Choose different drugs for treatment. Moreover, there are disadvantag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61K9/19A61P31/12
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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