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Eye preparation containing sodium hyaluronate for treating fundus macular degeneration and its preparation method

An ophthalmic preparation, a technology of sodium hyaluronate, applied in the field of ophthalmic preparations and its preparation, can solve problems such as inconvenient use and poor reducibility, and achieve the effect of keeping the eyes moist

Active Publication Date: 2007-05-02
SHANGHAI SINE PHARMA LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor reducibility of this type of gel, it is also inconvenient to use, because it must be used and stored at low temperature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0046] Preparation Example 1: Preparation of digitalis leaf dry extract

[0047] Digitalis purpurea leaves (Digitalis purpurea L. or digitalis lanata Ehrh. dry leaves of Scrophulariaceae plant digitalis purpurea L. or dried leaves of digitalis lanata Ehrh.) are used as raw materials to prepare digitalis leaf dry extract, which specifically includes the following steps:

[0048] (1) The digitalis leaves (place of origin: Shanghai) were pulverized, then placed in a normal-pressure reflux device, and 5 times the amount (volume) of 70% ethanol was added. Then, reflux extraction at 60° C. for 90 minutes;

[0049] (2) Repeat step (1) 3 times;

[0050] (3) The obtained extracts were combined, and concentrated under reduced pressure until the alcohol content was 20%, to obtain a concentrated solution. The resulting concentrate was refrigerated at 4°C overnight. Filter the next day, take the supernatant, extract 3 times with 1 / 10 of the amount (in terms of the volume of the supernat...

preparation example 2

[0052] Preparation Example 2: Preparation of Aescin

[0053] In Qinpi coarse powder (Chinese medicine Qinpi, derived from Fraxinus rhynchophylla Hanee, Fraxinus chinensis Roxb., Fraxinusszaboana Lingelsh. or Fraxinus stylosaLing, produced in Gansu) (20 mesh) in 1 kg Add 10 liters of water, and extract under reflux for 1 hour. Then the residue was extracted twice with water, each time adding 8 liters of water, and the reflux time was 1 hour. The extracts were combined, and the obtained extracts were directly added to AB-8 resin (Chemical Plant of Nankai University, Tianjin), and loaded at 3 column volumes per hour. After the sample is loaded, elute with 30 liters of water. After the eluate is clarified, start to collect the eluate, and stop collecting until 20 liters of eluate are collected. The collected 20 liters of eluate was concentrated to 1 liter and then left overnight in the refrigerator. The next day, filter the refrigerated concentrate and wash the filter cake with...

Embodiment 1

[0055] Digitalis Leaf and Escin Eye Drops

[0056] Water for injection 1000ml contains:

[0057] Digitalis leaf dry extract 0.05g

[0058] Aescin 0.1g

[0059] Sodium Hyaluronate 2.0g

[0060] Sodium chloride 8.4g

[0061] Benzalkonium Chloride 0.1g

[0062] Preparation Process:

[0063] 1. Add sodium hyaluronate to 250ml of water for injection, and swell at room temperature to obtain a fully swollen sodium hyaluronate solution.

[0064] 2. Dissolve sodium chloride and benzalkonium chloride in 500ml of water for injection, then add to the fully swollen sodium hyaluronate solution, stir evenly to obtain a mixed solution, and let it stand for use.

[0065] 3. Add the dry extract of digitalis leaves and esculetin to the mixed solution obtained in step 2, and stir evenly to obtain a solution.

[0066] 4. Adjust the pH of the solution obtained in step 3 to 6.0 with hydrochloric acid.

[0067] 5. Add 250ml of water for injection to the solution obtained in step 4, stir well ...

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PUM

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Abstract

An ocular medicine for treating fundus macular degeneration is prepared from foxglover leaf, aescin, sodium hyaluronate, and pharmacologically acceptable carrier. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to an ophthalmic preparation containing sodium hyaluronate and a preparation method thereof, more specifically to an ophthalmic preparation containing sodium hyaluronate digitalis leaves and aescin glycoside and a preparation method thereof. Background technique [0002] Digitalis Leaf and Aescin Eye Drops (foreign trade name: Stulln Mono, produced by Germany See Turin Pharmaceutical Factory) are clinically used for the treatment of macular degeneration, all types of eye fatigue and retinal Diseases related to the macula. [0003] In 1998, Gunther Kahtle clinically applied StullaMonon to treat age-related macular degeneration (AMD). After 28 days, the near and far vision of the patient was checked, and it was found that there was a significant improvement (P<0.01). Therefore, it is generally believed that the two vasoactive ingredients contained in the drug, "digital leaves" and "escin", can improve the microcirculation of th...

Claims

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Application Information

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IPC IPC(8): A61K36/80A61K31/728A61K9/08A61K9/00A61P27/02
Inventor 朱正鸣乌旭琼夏凌云
Owner SHANGHAI SINE PHARMA LAB
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