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Oral microemulsion of gingko leaf and preparation method thereof

A technology of ginkgo biloba and microemulsion, applied in medical raw materials derived from ginkgo biloba, emulsion delivery, blood diseases, etc., can solve problems such as unstable properties

Inactive Publication Date: 2007-04-25
杨铁耀
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The particle size of the microemulsion is generally less than 100nm, the appearance is transparent, and the property is stable; while the emulsion particle of the general emulsion is 1-100 μm, the appearance is milky white, opaque, and the property is unstable.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] prescription:

[0028] Ginkgo biloba extract 8g

[0029] Tween-80 15g

[0030] Isopropanol 15g

[0031] Cyclamate 4g

[0032] Sodium Alginate 2g

[0033] Sodium metabisulfite 1g

[0034] Deionized water 955g

[0035] Total 1000g

[0036] Preparation:

[0037] (1) get the emulsifying agent of recipe quantity, auxiliary emulsifying agent, stir and mix, make (I), for subsequent use;

[0038] (2) get the Ginkgo biloba extract of recipe quantity, stir and mix with (I), make evenly, make (II), for subsequent use;

[0039] (3) get flavoring agent, thickener of recipe quantity, dissolve with deionized water, make (III), for subsequent use;

[0040] (4) Slowly add (III) into (II), stir and mix microemulsion while adding, and filter to obtain microemulsion (IV), set aside;

[0041] (5) After the microemulsion (IV) is qualified after inspection, it can be packed, stoppered and capped;

[0042] (6) autoclaved steam sterilization, to obtain.

Embodiment 2

[0044] prescription:

[0045] Ginkgo biloba extract 8g

[0046] Polyoxyethylene hydrogenated castor oil 10g

[0047] Propylene glycol 8g

[0048] Aspartose 8g

[0049] Hypromellose 1g

[0050] Deionized water 965g

[0051] Total 1000g

[0052] Preparation method: with embodiment 1.

Embodiment 3

[0054] prescription:

[0055] Ginkgo biloba extract 8g

[0056] Labrasol 8g

[0057] Glycerin 12g

[0058] Cyclamate 8g

[0059] Sodium chloride 4g

[0060] Deionized water 960g

[0061] Total 1000g

[0062] Preparation method: with embodiment 1.

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PUM

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Abstract

The invention relates to an oral micro-emulsion of ginkgo leaf and its preparing process, wherein the micro-emulsion is prepared from total ginkgo flavonoids, terpene lactones, deionized water, emulsifying agent, assistant emulsifier, flavoring agent, thickening agent and anti-oxidant through steps of weighing, proportioning, stirring, mixing, micro-emulsifying, canning and sterilizing.

Description

technical field [0001] The invention relates to a ginkgo leaf oral microemulsion in the form of microemulsion and a preparation method thereof. Background technique [0002] Ginkgo biloba is the dried leaf of Ginkgo biloba L., a plant of the family Ginkgoaceae. Ginkgo biloba, Ginkgo biloba extract, and Ginkgo biloba leaves have been recorded in the Chinese Pharmacopoeia 2005. Ginkgo biloba extract contains total flavonoid glycosides and terpenoids Lactone and other active ingredients, modern pharmacological studies have shown that Ginkgo biloba extract has the effect of anti-platelet activating factor, can reduce blood viscosity and red blood cell aggregation, change blood fluidity; can enhance myocardial ischemic preconditioning, improve Coronary circulation; and has anti-free radicals, improve the immune function of the body and so on. There are many dosage forms of Ginkgo biloba extract, including tablets, capsules, soft capsules, injections, granules, and oral liquids. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K9/107A61P7/02A61P9/10
Inventor 杨铁耀
Owner 杨铁耀
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