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Medicine composition contg. Poria cocos and Touhualiao (polygonaceae)

A composition, the technology of Polygonum cephalum, applied in the field of medicine, achieves the effects of high safety, less impurities, and high purity of medicines

Inactive Publication Date: 2007-04-18
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Utilizing the interaction of Polygonum cephalosporin and Poria cocos, and combining prescriptions to prepare medicines for treating nephritis, cystitis, urinary calculi, etc., there is no report yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0146] Example 1 Preparation of Polygonum cephalum extract

[0147] Take 500kg of Polygonum cephalum medicinal material, chop it up, add water to decoct twice, each time for 2 hours, filter, concentrate the filtrate under reduced pressure to a relative density of 1.10-1.15, let it cool, add ethanol to make the alcohol content to 60%, and refrigerate for 24 hours, filter, and recover the ethanol from the filtrate until there is no alcohol smell, add it to the treated polyamide column (30-60 mesh, ethanol wet packing, pre-wash with appropriate amount of ethanol, then wash with water until there is no alcohol smell, set aside) , wash with 2 times the column volume of water, then wash with 2 times the column volume of 10% ethanol, discard the washing solution, and then elute with 3 times the column volume of 70% ethanol, collect the eluate, recover the ethanol and concentrate Form into a concentrated solution with a relative density of 1.08 to 1.12, and spray dry to obtain.

[01...

Embodiment 2

[0167] Example 2 Preparation of Poria cocos extract

[0168] Weigh 500 kg of Poria cocos, crush it into fine powder, add 0.5mol / L sodium hydroxide solution to extract twice, stir, add 8 times the amount of solvent for the first 4 hours, and add 6 times the amount of solvent for the second 3 hours , stirred at low temperature, suction filtered, combined filtrates, neutralized with 10% acetic acid, refrigerated for 12 hours, and filtered. The precipitate was washed successively with water, acetone and ether, and dried to obtain the obtained product.

[0169] A total of 41.2 kg of Poria cocos extract was obtained, with a yield of 8.24%.

[0170] Identification Test of Poria Cocos Extract

[0171] (1) Take 1g of this product powder, add 10ml of acetone, heat and reflux for 10 minutes, filter, evaporate the filtrate to dryness, add 1ml of glacial acetic acid to dissolve the residue, add 1 drop of sulfuric acid, it will appear light red, and then turn brown.

[0172] (2) Take a s...

Embodiment 3

[0178] Example 3 Preparation of aqueous injection of the pharmaceutical composition of the present invention

[0179] prescription:

[0180] Polygonum officinalis extract 105g (equivalent to 10kg of the original medicinal material of Polygonum officinalis)

[0181] Poria cocos extract 825g (equivalent to 10kg of Poria cocos raw material)

[0182] Add water for injection to 10000ml

[0183] A total of 1000 sticks were prepared

[0184] Preparation Process:

[0185] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0186] 2) Take water for injection with a dosing volume of 80%, add Polygonum cephalosporin extract and Poria cocos extract in prescription volume, heat and stir to dissolve completely.

[0187] 3) Add water for injection to the full amount.

[0188]4) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.

[0189] 5) Decarburiz...

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PUM

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Abstract

A composite Chinese medicine for treating nephritis, cystitis, and urethra calculus is proportionally prepared from Touhua knotweed or its extract and tuckahoe or its extract.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition mainly composed of Polygonum cephalum or Polygonum cephalum extract and Poria cocos or Poria cocos extract and a preparation method thereof, belonging to the technical field of medicine. 2. Background technology [0002] Polygonum capitatum, also known as Sijihong and Shimangcao, is the whole herb of Polygonum capitatum Buch-Ham ex D.Don, a plant of the Polygonum family. It is distributed in southwest my country and is a commonly used medicine in ethnic minority areas. Polygonum cephalum has the effects of clearing away heat and detoxification, diuresis and treating stranguria. It is mainly used to treat nephritis, cystitis, dysentery, urinary calculus, rheumatic pain, sore eczema and other diseases. Its water extract can significantly reduce the white blood cells in the urine of rat pyelonephritis model. and red blood cells, significantly reducing t...

Claims

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Application Information

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IPC IPC(8): A61K36/70A61K36/076A61K9/08A61P13/12A61P13/10A61P13/04
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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