Traditional Chinese medicinal formulation for treating ischemic cardiovascular and cerebrovascular diseases and preparation method thereof
A technology for cardiovascular and cerebrovascular diseases and traditional Chinese medicine preparations, which is applied to cardiovascular system diseases, medical preparations containing active ingredients, and pill delivery. problems, to achieve the effect of fast dissolution rate, difficult hydrolysis and high bioavailability
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Embodiment 1
[0045] Preparation Process
[0046] 1250g of Salvia miltiorrhiza and 1250g of Pueraria lobata root were crushed into the coarsest powder, and 10 times the amount of 80% ethanol was added to soak at room temperature for 5 times, each time for 48 hours, and the soaking solutions were combined. Ethanol is recovered under reduced pressure and concentrated, filtered, and the filtrate is passed through a macroporous adsorption resin AB-8 column, and the resin bed is washed with an aqueous hydrochloric acid solution of pH 7 with 10 times the volume of the column. Elution, collect the eluent, recover ethanol under reduced pressure, concentrate, vacuum dry to obtain dry extract, pulverize and set aside.
[0047] Chuanxiong powder 1250g was crushed into the coarsest powder, added 10 times the amount of 90% ethanol and soaked at room temperature for 5 times, each time for 48 hours, and combined the soaking solution. Ethanol was recovered under reduced pressure, concentrated, and separat...
Embodiment 2
[0053] Preparation Process
[0054] 1250g of Salvia miltiorrhiza and 1250g of Pueraria lobata root were crushed into the coarsest powder, added twice the amount of 40% ethanol and soaked twice at room temperature for 12 hours each time, and the soaking solutions were combined. Ethanol was recovered under reduced pressure and concentrated, filtered, and the filtrate was passed through a macroporous adsorption resin D101 column, and the resin bed was washed with an aqueous hydrochloric acid solution of pH 2 with 3 times the volume of the column, and eluted with 30% ethanol with 2 times the volume of the column after washing the column , collect the eluent, recover ethanol under reduced pressure, concentrate, and vacuum-dry to obtain a dry extract, which is pulverized and set aside.
[0055] Chuanxiong 1250g was crushed into the coarsest powder, added 2 times the amount of 60% ethanol and soaked twice at room temperature for 12 hours each time, and combined the soaking solution. ...
Embodiment 3
[0061] Preparation Process
[0062] 1250g of Salvia miltiorrhiza and 1250g of Pueraria lobata root were crushed into the coarsest powder, added 5 times the amount of 60% ethanol and soaked at room temperature for 4 times, each time for 20 hours, and combined the soaking solutions. Ethanol is recovered under reduced pressure and concentrated, filtered, and the filtrate is passed through a macroporous adsorption resin AB-8 column, and the resin bed is washed with an aqueous hydrochloric acid solution of pH 3 with 5 times the volume of the column. Elution, collect the eluent, recover ethanol under reduced pressure, concentrate, vacuum dry to obtain dry extract, pulverize and set aside.
[0063] Chuanxiong 1250g was crushed into the coarsest powder, added 4 times the amount of 70% ethanol and soaked twice at room temperature for 20 hours each time, and combined the soaking solution. Ethanol was recovered under reduced pressure, concentrated, and separated into layers to obtain th...
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