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Preparing method and application of nano shen-qi-fu-zheng injectio

A technology of ginseng strengthening the body and injection preparations, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, powder delivery, etc., which can solve the problems of poor practicability and achieve pain relief, good safety, and improved stability Effect

Inactive Publication Date: 2007-03-07
北京联合伟华药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The patent application No. 01100151.8 "Nano-Shenqi Preparation Drug and Its Preparation Method" simply crushed Codonopsis pilosula and Astragalus membranaceus into nano-scale particles, and there was no pharmacological test to prove the pharmacological effect of the preparation, but only generally speaking of biological Utilization is improved, practicality is not strong

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] Take 400g of Codonopsis pilosula and Astragalus membranaceus, crush them into coarse powder, add deionized water to heat and extract 3 times, and the amount of water added each time is 8 times, 6 times, and 6 times respectively. The decocting time is 1 hour, 1 hour, 0.5 hour respectively, combine the extracts for 3 times, concentrate until the crude drug content per 1ml is about 1.0-1.5g, add ethanol under stirring, so that the ethanol content reaches 60%, stir well After standing still for 24 hours, filter, recover ethanol from the filtrate and concentrate to contain 1.8-2.2g of crude drug per 1ml, add ethanol under stirring to make the ethanol content reach 80%, and let it stand in a cold place (2-10°C) after fully stirring After 24 hours, filter, and recover ethanol from the filtrate to dryness under reduced pressure, and concentrate to a crude drug content of 1.8-2.2 g per 1 ml, to obtain the effective part of the ginseng root of the present invention.

Embodiment 2

[0120] (1) Take 5g of the effective part, 12g of soybean lecithin and 18g of glyceryl trilaurate, heat it to 75°C under the condition of nitrogen, add 4g of glycerin at the same temperature and 20g of poloxamer-188 in aqueous solution under the condition of stirring, and make crude For the milk, use a high-pressure milk homogenizer (or high-speed shear milk homogenizer) at 80°C under a nitrogen atmosphere to homogenize the milk for 6 times under a pressure of 41.4 MPa. After being filled with nitrogen and divided into packages, it is rapidly cooled to form a main drug suspension.

[0121] (2) Preparation of preparation:

[0122] Preparation of aqueous injection preparation: take the above suspension, add an appropriate amount of PVP, add water for injection to the full amount, stir well, adjust the pH value to 6.5-7.5, filter with a 0.22 μm microporous membrane, and sterilize to prepare the nano-ginseng of the present invention. Qifuzheng Water Injection Preparation 1000 stick...

Embodiment 3

[0127] (1) Take 10g of the effective part, 24g of egg yolk lecithin and 36g of glyceryl tristearate, heat it to 84°C under nitrogen, add 6g of glycerin at the same temperature and 35g of poloxamer-188 in aqueous solution under stirring to prepare Coarse milk, homogenize 4 times with a high-pressure homogenizer (or high-speed shear homogenizer) under a pressure of 42MPa at 88°C under nitrogen, and then cool down rapidly to form a suspension of the main drug after filling with nitrogen.

[0128] (2) Preparation of preparation:

[0129] Preparation of aqueous injection preparation: take the above suspension, add an appropriate amount of PVP, add water for injection to the full amount, stir well, adjust the pH value to 6.5-7.5, filter with a 0.22 μm microporous membrane, and sterilize to prepare the nano-ginseng of the present invention. Qifuzheng Water Injection Preparation 1000 sticks;

[0130] Preparation of infusion preparations: take the above suspension, add appropriate amo...

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PUM

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Abstract

The invention relates to a method for preparing nanometer stewed corrected injection, and relative application. Wherein, it prepares the total extractive of stewed mutton with ginseng and astragalus and astragalus root, with some findings, into nanometer carriers, to be made into water injection, frozen dried, etc. The inventive product has significant target function, better solution, and stable property. And it has low excitation. The invention can reduce the ache of cancer patient. And it can improve immunity, etc.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method and an application of a nano-shenqi Fuzheng injection preparation. Background technique [0002] Nano Chinese medicine mainly refers to the active ingredients, active parts, original medicines and compound preparations of traditional Chinese medicines with a particle size of less than 100 nanometers manufactured by nanotechnology. The preparation of nanometer traditional Chinese medicine is the most basic and important issue in the study of nanometer traditional Chinese medicine. When nanotechnology is introduced into the research of traditional Chinese medicine, the diversity of traditional Chinese medicine prescriptions and the complexity of traditional Chinese medicine ingredients must be considered. The active parts and active ingredients of traditional Chinese medicine include inorganic compounds and organic com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/14A61P1/14A61P37/02A61P35/00
Inventor 张树祥阚迎昕
Owner 北京联合伟华药业有限公司
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