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Slowly released tablet of compound atenolol, and preparation method

A sustained-release tablet and compound technology, which is applied in the field of medicine, can solve problems such as difficult erosion release synchronous coordination, low bioavailability, prolonging the period of medication, etc., achieve important economic value and social significance, reduce drug costs, reduce The effect of adverse reactions

Inactive Publication Date: 2007-02-21
山东益康药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing compound preparations are all regular-release preparations, and most of them are taken twice a day. Compared with atenolol or nifedipine alone, although there are many conveniences, there are still shortcomings such as missed doses and high cost.
The Chinese patent application number 03123923.4 discloses a compound atenolol and nifedipine sustained-release preparation made from the existing single sustained-release preparations of atenolol and nifedipine, in order to achieve its joint sustained-release effect , to achieve the purpose of prolonging the medication period, but due to the different half-life characteristics of atenolol and nifedipine, although it considers the slow release, it is difficult to make the erosion, diffusion, release and The drug effects in the body are synchronized and coordinated, the bioavailability is not very high, and adverse reactions occur from time to time

Method used

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  • Slowly released tablet of compound atenolol, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Unit prescription of compound atenolol sustained-release tablets (1000 tablets, specification: atenolol 50mg, nifedipine 20mg / tablet), in which:

[0062] Immediate-release granules A contain:

[0063] Atenolol 50g

[0064] Nifedipine 5g

[0065] Lactose 10g

[0066] Talc 1.0%

[0067] 5% PVPk 30 80% ethanol solution in appropriate amount

[0068] Sustained-release granules B contain:

[0069] Nifedipine 15g

[0070] PEG6000 60g

[0071] Hypromellose (K 15M ) 70g

[0072] Talc 1.0%

[0073] 5% PVPk 30 An appropriate amount of 80% ethanol solution.

[0074] The preparation method of the above-mentioned compound atenolol sustained-release tablet is to mix atenolol with a small amount of nifedipine to make quick-release granules A, as the quick-release layer, use the hydrophilic gel skeleton material PEG6000 to make the remaining nifedipine Dipine is made into a solid dispersion and then mixed with a slow-release material to make a slow-release granule B as a s...

Embodiment 2

[0077] Unit prescription of compound atenolol sustained-release tablets (1000 tablets, specification: atenolol 50mg, nifedipine 20mg / tablet), in which:

[0078] Immediate-release granules A contain:

[0079] Atenolol 50g

[0080] Nifedipine 5g

[0081] Lactose 3g

[0082] Talc 0.5%

[0083] 5% PVPk 30 80% ethanol solution in appropriate amount

[0084] Sustained-release granules B contain:

[0085] Nifedipine 15g

[0086] PEG6000 60g

[0087] Hypromellose (K 15M ) 15g

[0088] Talc 0.5%

[0089] 5% PVPk 30 An appropriate amount of 80% ethanol solution.

[0090] The preparation method of the above-mentioned compound atenolol sustained-release tablet is to mix atenolol with a small amount of nifedipine to make quick-release granules A, as the quick-release layer, use the hydrophilic gel skeleton material PEG6000 to make the remaining nifedipine Dipine is made into a solid dispersion and then mixed with a slow-release material to make a slow-release granule B as a slow...

Embodiment 3

[0093] Unit prescription of compound atenolol sustained-release tablets (1000 tablets, specification: atenolol 50mg, nifedipine 20mg / tablet), in which:

[0094] Immediate-release granules A contain:

[0095] Atenolol 50g

[0096] Nifedipine 5g

[0097] Lactose 24g

[0098] Talc 2.0%

[0099] 5% PVPk 30 80% ethanol solution in appropriate amount

[0100] Sustained-release granules B contain:

[0101] Nifedipine 15g

[0102] PEG6000 60g

[0103] Hypromellose (K 15M ) 140g

[0104] Talc 2.0%

[0105] 5% PVPk 30 An appropriate amount of 80% ethanol solution.

[0106] The preparation method of the above-mentioned compound atenolol sustained-release tablet is to mix atenolol with a small amount of nifedipine to make quick-release granules A, as the quick-release layer, use the hydrophilic gel skeleton material PEG6000 to make the remaining nifedipine Dipine is made into a solid dispersion and then mixed with a slow-release material to make a slow-release granule B as a ...

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Abstract

A slow-release tablet of compound atenolol is prepared through preparing fast-release particle from atenolol and less nifedipine, preparing its slow-release layer from hydrophilic gel PEG6000, rest of nifedipine and slow-release material, and die pressing.

Description

technical field [0001] The invention relates to a sustained-release tablet and a preparation method thereof, in particular to a compound atenolol sustained-release tablet and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Hypertension is a common chronic disease and a major risk factor for cardiovascular and cerebrovascular diseases. In recent years, with the rapid development of medical technology, the types and varieties of antihypertensive drugs are also increasing, and the antihypertensive effect is also significantly improved. Among them, β-receptor blockers and calcium antagonists (CCB) are listed as WHO / ISH The recommended first-line antihypertensive drugs have satisfactory clinical efficacy. [0003] Atenolol and nifedipine are commonly used clinical antihypertensive drugs. [0004] Atenolol as beta 1 Receptor blockers, oral administration is used to treat various degrees of hypertension. The antihypertens...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/165A61K31/4422A61P9/12
Inventor 邓树海高肇林满其永
Owner 山东益康药业股份有限公司
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