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New usage of tandospirone and its derivative, and composition containing tandospirone

A technology of tandospirone and composition, which is applied in the field of compositions containing tandospirone to achieve the effect of improving bioavailability

Inactive Publication Date: 2007-02-21
SICHUAN CREDIT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, there is no report on tandospirone and its derivatives for oral administration

Method used

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  • New usage of tandospirone and its derivative, and composition containing tandospirone
  • New usage of tandospirone and its derivative, and composition containing tandospirone
  • New usage of tandospirone and its derivative, and composition containing tandospirone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Preparation of orally disintegrating tablets of tandospirone

[0030] Tandospirone 3g (about 0.008mol)

[0031] Low-substituted hydroxypropyl methylcellulose 30g

[0032] Lactose starch 84g

[0033] Mannitol 79g

[0034] Sweet orange essence 2g

[0035] Magnesium Stearate 2g.

[0036] Preparation method: 1. Pass the raw and auxiliary materials through a 100-mesh sieve;

[0037] 2. Mix the prescribed amount of tandospirone citrate and low-substituted hypromellose in a mixer, and continue to add the remaining amount of low-substituted hypromellose in equal amounts, mix evenly, and then Add mannitol, lactose starch in turn, and finally add sweet orange essence and magnesium stearate and mix well;

[0038] 3. Determine the content, calculate the tablet weight, and directly compress the powder into tablets, making a total of 1,000 tablets, and controlling the hardness to 1.5-2.5kg;

[0039] ...

Embodiment 2

[0040] Example 2 Preparation of Sublingual Tablets of Tandospirone Citrate

[0041] Tandospirone citrate 5g (about 0.008mol)

[0042] Low Substituted Hydroxypropyl Methyl Cellulose 120g

[0043] Lactose starch 60g

[0044] Mannitol 10g

[0045] Sweet orange essence 2g

[0046] Magnesium stearate 1g.

[0047] Preparation method: 1. Pass the raw and auxiliary materials through a 100-mesh sieve

[0048] 2. Mix the prescribed amount of tandospirone citrate and low-substituted hypromellose in a mixer, and continue to add the remaining amount of low-substituted hypromellose in equal amounts, mix evenly, and then Add mannitol, lactose starch in turn, and finally magnesium stearate and mix well.

[0049] 3. Measure the content, calculate the tablet weight, and directly compress the powder into tablets, making a total of 1000 tablets, controlling the hardness to 1.5-2.5kg, and the tablet weight to 0.3g.

[0050] ...

Embodiment 3

[0051] Example 3 Preparation of Sublingual Tablets of Tandospirone

[0052] Tandospirone 10g (about 0.027mol)

[0053] Low Substituted Hypromellose 110g

[0054] Lactose starch 63g

[0055] Mannitol 12g

[0056] Sweet orange essence 2g

[0057] Magnesium stearate 1g.

[0058] Preparation method: 1. Pass the raw and auxiliary materials through a 100-mesh sieve

[0059] 2. Mix the prescribed amount of tandospirone citrate and low-substituted hypromellose in a mixer, and continue to add the remaining amount of low-substituted hypromellose in equal amounts, mix evenly, and then Add mannitol, lactose starch in turn, and finally sweet orange essence and magnesium stearate and mix well.

[0060] 3. Measure the content, calculate the tablet weight, and directly compress the powder into tablets, making a total of 1000 tablets, controlling the hardness to 1.5-2.5kg, and the tablet weight to 0.3g.

[0061] 4. ...

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Abstract

An application of the tandospirone and its derivatives in preparing the locally applied medicine for treating anxiety by sublingual mucosa absorption is disclosed.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the new application of tandospirone and its derivatives and the composition containing tandospirone. Background technique [0002] Anxiety is the most common emotional reaction and a central symptom of all neuroses. With the development of society and the accelerated pace of life, people's demand for anti-anxiety drugs is increasing day by day. The 5-HT receptor agonist drug—tandospirone (tandospirone, trade name: Xidejing) was successfully developed by Sumitomo Pharmaceutical Co., Ltd. of Japan. Approved for marketing in Japan in 1996, it is sold in the market in the form of ordinary tablets of tandospirone citrate, and there is no report about other dosage forms so far. [0003] Ordinary tablets need to be taken with the help of drinking water and swallowing actions. This dosage form is used for some acute patients with difficulty swallowing or special circumstances, such as the elde...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/20A61K9/12A61K31/506A61P25/22
Inventor 陈刚陈功政刁健代竹青
Owner SICHUAN CREDIT PHARMA
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