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Infection resistant polychloroethylene material and process for preparing same

A technology of polyvinyl chloride and polyvinyl chloride resin, which is applied in medical science, surgery, etc., can solve the problems of limited application range and poor transparency of polyvinyl chloride materials, and achieve reliable anti-infection performance, long effective action time, and material adaptable effect

Inactive Publication Date: 2007-02-07
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention selects a suitable organic, inorganic or organic / inorganic mixed anti-infective agent that does not damage the transparency of the polyvinyl chloride material, compounding and blending the anti-infective agent and other auxiliaries with the medical polyvinyl chloride material and extruding The method prepares the medical anti-infection polyvinyl chloride material with anti-infection function as a whole, and solves the problem that the current medical anti-infection polyvinyl chloride material has poor transparency and limited application range under the premise of maintaining the basic characteristics of the current medical anti-infection polyvinyl chloride material. Limited disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Mix 2000 grams of medical-grade polyvinyl chloride compound YGD-1, 15 grams of glass-carried silver anti-infection agent, 20 grams of EBS, and 20 grams of rare earth stabilizer XR in a clean 5L high-speed mixer, and mix them uniformly in a φ20 single-screw The extruder extrudes at a temperature of 140-160 DEG C, granulates with a pelletizer, and packs to obtain the medical anti-infection polyvinyl chloride of the present invention. This material is used to make transparent drainage tubes. The material is subjected to toxicological testing according to the requirements of GB / T16886-1997 "Biological Evaluation of Medical Devices" and GB15593 "Soft PVC Plastics for Blood (Liquid) Devices", and the prepared drainage tube is compared with the ordinary drainage tube. The test and experimental results are shown in Table 4.

Embodiment 2

[0052]Put 5000 grams of medical grade polyvinyl chloride VM1170E, 20 grams of 3-hydroxytrichlorodiphenyl ether, 30 grams of chlorhexidine, 200 grams of silicon-containing lubricating masterbatch MB50-003, and 75 grams of magnesium aluminum hydrotalcite in a clean 10L high-speed After fully mixing in a mixer, extrude in a φ40 single-screw extruder at a temperature of 150-170° C., granulate with a pelletizer, and pack to obtain the medical anti-infection polyvinyl chloride of the present invention. This material is used to make transparent endotracheal tubes. The material is subjected to toxicological testing in accordance with the requirements of GB / T16886-1997 "Biological Evaluation of Medical Devices" and GB15593 "Soft Polyvinyl Chloride Plastics for Blood (Liquid) Devices", and the prepared tracheal intubation is compared with ordinary tracheal intubation Experiment, test, and experimental results are shown in Table 4.

Embodiment 3

[0054] Put 3000 grams of medical polyvinyl chloride resin TK1300N, 45 grams of nano-sized zirconium phosphate silver-loaded anti-infection agent, 30 grams of 3-hydroxytrichlorodiphenyl ether, 60 grams of 2-hydroxystearic acid, and 50 grams of calcium-zinc stabilizer Put into the high-mixing mixer unit and stir at high speed until the material temperature reaches 65°C, slowly add 1 kg of bis(2-ethylhexyl)phthalate (DEHP), stir at low speed until 105°C, and then use φ40 single screw The extruder extrudes at a temperature of 150-170 DEG C, granulates with a pelletizer, and packs to obtain the medical anti-infection polyvinyl chloride of the present invention. This material is used to make transparent tracheostomy sleeves. The material is toxicologically tested in accordance with the requirements of GB / T16886-1997 "Biological Evaluation of Medical Devices" and GB15593 "Soft Polyvinyl Chloride Plastics for Blood (Liquid) Devices". The bushing was subjected to a comparative experim...

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PUM

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Abstract

The invention relates to an anti-infection polychloroethylene material and relative preparation, wherein it is based on medical polychloroethylene mixture, with anti-infection agent, lubricant modifier, disperse agent and stabilizer; or based on medical polychloroethylene resin, with anti-infection agent, elasticizer, lubricant modifier, disperse agent and stabilizer; the anti-infection agent is Ag+ anti-infection agent whose carrier is glass, the Ag+ anti-infection agent whose diameter is nanometer level, and carrier is basic zirconium phosphate, and the mixture of 3-carbonel trichloroanisole or chlorhexidine. The invention uses the anti-infection agent that will not affect the penetration of polychloroethylene material, to mix the anti-infection agent with other agents and medical polychloroethylene material, to be extruded to prepare the product, which can keep the basic character of anti-infection agent and expand the application.

Description

technical field [0001] The invention relates to a polyvinyl chloride (PVC) material used for preparing medical equipment, in particular to an anti-infection medical polyvinyl chloride material prepared by adding anti-infective agents and other auxiliary agents and a preparation method thereof. Background technique [0002] Due to the excellent performance, diverse structures and wide applicability of polymer materials, it is a trend in the development of the international medical device industry to replace traditional materials such as metals with medical polymer materials, and it has achieved rapid development in recent years. . According to statistics, in 1995, the cost of polymer materials consumed in medical devices in the world exceeded 12 billion U.S. dollars, and it was increasing at an average annual growth rate of 7-12% (S Ramakrishna, J Mayer, EWintermantel, et al, Biomedical applications of polymer - compositematerials:: a review, Composites Science and Technolog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04
Inventor 叶钢季君晖张伟民严庆
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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