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Preparation method of super large pore polymer microsphere and its product

A technology of ultra-large pores and polymers, which is applied in the interdisciplinary fields of polymer materials and biochemical engineering, and can solve problems such as unsuitable scale-up, cumbersome preparation process, and complicated formula

Active Publication Date: 2007-01-31
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high volume content of the water phase in the high internal phase emulsion and poor stability, many factors such as the hydrophobicity / hydrophilicity and volume fraction of the oil phase monomer, the type and concentration of the surfactant, the viscosity of the continuous phase, and the polymerization temperature will affect the stability of the emulsion. Its influence and improper control can easily cause demulsification, resulting in failure to form microspheres
[0008] Aiming at the shortcomings of the above-mentioned several preparation technologies, such as troublesome preparation process, complex formula, and unsuitable scale-up, the present invention provides a simple and feasible method for preparing super-macroporous bio-separation media

Method used

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  • Preparation method of super large pore polymer microsphere and its product
  • Preparation method of super large pore polymer microsphere and its product
  • Preparation method of super large pore polymer microsphere and its product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Accurately weigh 37.5g of styrene and 12.5g of divinylbenzene into a 100mL beaker, add 2.0g of benzoyl peroxide, 25.0g of hexadecane and 35.0g of span80, and stir until the initiator is completely dissolved. Dissolve 1.0g of PVA in 500mL of distilled water to form the water phase. The oil phase was added to the water phase, stirred at a speed of 200 rpm, nitrogen gas was passed for 1 h, and polymerized at 75° C. for 24 h. After the reaction is finished, filter, wash the product several times with distilled water and ethanol, wash the diluent, surfactant and other components, and dry to obtain the product. The electron micrographs of the obtained microspheres are as follows: figure 1 shown. Characterize the microsphere structure and measure: the specific surface area is 126.9m 2 / g, the porosity is 65.5%, the density is 0.40g / mL, and it has two kinds of pore distribution, one is super large pores of 1-60μm, and the other is small pores of 30-100nm, such as figure 2 ...

Embodiment 2

[0041] Accurately weigh 35.0g of styrene and 15.0g of divinylbenzene into a 100mL beaker, add 2.0g of benzoyl peroxide, 35.0g of hexadecane and 45.0g of span80, and stir until the initiator is completely dissolved. Dissolve 1.0g of PVA in 500mL of distilled water to form the water phase. The oil phase was added to the water phase, stirred at a speed of 200 rpm, nitrogen gas was passed for 1 h, and polymerized at 75° C. for 24 h. After the reaction is finished, filter, wash the product several times with distilled water and ethanol, wash the diluent, surfactant and other components, and dry to obtain the product. The electron micrographs of the obtained microspheres are as follows: image 3 shown. Characterize the microsphere structure and measure: the specific surface area is 203.8m 2 / g, the porosity is 83.6%, and the density is 0.31g / mL. It mainly has two kinds of pore distribution, one is super large pores of 1-60μm, and the other is small pores of 200-800nm, such as F...

Embodiment 3

[0043] Accurately weigh 37.5g of styrene and 12.5g of divinylbenzene into a 100mL beaker, add 1.5g of azobisisobutyronitrile, 25.0g of hexadecane and 35.0g of span80, and stir until the initiator is completely dissolved. Dissolve 1.0g of PVA in 500mL of distilled water to form the water phase. The oil phase was added to the water phase, stirred at a speed of 200 rpm, nitrogen gas was passed for 1 h, and polymerized at 75° C. for 24 h. After the reaction is finished, filter, wash the product several times with distilled water and ethanol, wash the diluent, surfactant and other components, and dry to obtain the product. The electron micrographs of the obtained microspheres are as follows: Figure 5 shown.

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Abstract

The present invention provides a preparation method of supermacroporous polymer microsphere and its product. It is characterized by that said preparation method includes the following steps: adding high-content surfactant into oil phase containing monomer, making the oil phase containing monomer and surfactant be dispersed in water phase, making the above-mentioned material undergo the process of suspension polymerization so as to obtain supermacroporous microsphere. The grain size of said microsphere is 1-200 micrometers, and its porosity is 10%-90%.

Description

field of invention [0001] The invention belongs to the interdisciplinary field of polymer materials and biochemical industry, relates to a method for manufacturing macroporous polymer microspheres, in particular to a method for preparing super-macroporous polymer microspheres with two types of pore distribution. Background of the invention [0002] With the development of life sciences, the separation of related biomacromolecules has become an extremely important topic. At present, the separation and purification technology for large-scale preparation of proteins has become a limiting factor in the development of biotechnology. A lot of research is going on at home and abroad, and this direction has also become one of the focuses of scientific and technological investment. [0003] Although the research on bioseparation media has a history of several decades, the performance of the media (such as mechanical strength, scope of application and service life) and its separation ...

Claims

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Application Information

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IPC IPC(8): C08F10/00C08F12/08C08F20/00C08F2/18C08F2/44
Inventor 马光辉苏志国周炜清
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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