Zhenqi medicinal composition and its preparation

Abstract

The Zhenqi medicinal composition is prepared with privet fruit and astragalus root as main material and proper amount of supplementary material. It contains several effective components and active components of middle and small molecular weight, including polysaccharide in 5.0-90 wt%, glycosides in 5.0-30 wt% and flavones in 1.0-20 wt%. It possesses functions of invigorating qi and nourishing Yin, and may be used in treating viscera asthenia and qi and Yin deficiency caused by diseases.

Description

technical field [0001] The invention relates to a chastity-qi drug combination and its preparation, belonging to the technical field of medicines. Background technique [0002] Zhenqi Fuzheng medicine preparation is made from the traditional Chinese medicine Astragalus membranaceus and Ligustrum lucidum, which has the function of nourishing qi and nourishing yin. It is used for prolonged illness and deficiency of qi and yin. It can be used in conjunction with surgery, radiation therapy, and chemotherapy to promote normal functions. recovery. According to modern pharmacological experiments, its pharmacological effects include: 1. Improve the immune function of the body; 2. Increase blood cells, protect bone marrow, adrenal cortex and liver function; 3. Promote the production of interferon. Clinical indications: 1. People with low immune function; 2. Depletion caused by various diseases, deficiency of qi and yin, elderly, infirm and sick patients, patients with chronic diseas...

AI Technical Summary

Problems solved by technology

Many domestic researchers have carried out a lot of research work, such as: the patent application number is "200310118934.7", the name is "Zhenqi Fuzheng drug preparation method improvement" application, the patent application number is "200510038192.6" and the name is "Zhenqi Fuzheng for injection" The application for freeze-dried powder injection preparation and its preparation method” and the patent application number “200510012502.7” and the application titled “Zhenqi Fuzheng Injection Preparation and Its Preparation Method”, although its products have certain clinical effects clinically, However, in the preparation methods, the extraction of active ingredients is not comprehensive, or there are many impurities in the macromolecular components such as mucus and gums in the extract, which makes the drug loading of the product unit dose low, resulting in insufficient drug efficacy. When the drug is released or the drug effect is reduced, the patient must increase the dose to achieve the therapeutic purpose, resulting in the patient taking too much excipients, bringing unnecessary burden and pain to the patient, and at the same time bringing hidden dangers to drug safety; according to the latest As a result of the research, Astragalus and Ligustrum lucidum contain a large amount of polysaccharides, glycosides, flavonoids and small and medium-sized active ingredients. Polysaccharides from Astragalus and Ligustrum lucidum have the effect of enhancing immune function. It has a variety of biological activities, and has the functions of anti-fatigue, anti-inflammation, and qi. Aging effect, enhancing T cell activity, anti-tumor effect, the results show that: astragalus, Ligustrum lucidum polysaccharide components, glycoside components, flavonoid components and small and medium molecular substances all have strong pharmacological effects, thus showing that the above preparation process Unreasonable; and in patent application number be " 200310122216.7 ", title is called the application of " preparation method improvement of Zhenqi Fuzheng medicine ", adopt the technique of macroporous adsorption resin enrichment active ingredient, remove more impurity, although method is good, but , it is very difficult to carry out the application of large-scale production, which greatly increases the process cost, and the market competitiveness is poor; and the extraction process only selects Ligustrum lucidum to extract the alcohol-soluble components, but does not extract the alcohol-soluble components of Astragalus, which greatly reduces The curative effect of the drug; most researchers use macroporous adsorption resin to refine the drug, but its organic residues will bring many toxicity and safety problems; in view of this situation, there is an urgent need for a product with more stable quality and reasonable and feasible process

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