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Aescine oral disintegrant tablet and its preparing method

A technology of orally disintegrating tablets and aescin, which is applied in the field of aescin orally disintegrating tablets and its preparation, can solve the problems such as the undiscovered information of aescin orally disintegrating tablets

Inactive Publication Date: 2007-01-24
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Checked patents and literature, found no information about aescin orally disintegrating tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] (1) Take 503 grams of saffron seeds, crush them, put them into an ultrasonic extraction tank, control the extraction temperature at 25°C, extract twice, 5 minutes each time, reserve the residue, combine the extracts, concentrate in a rotary scraper, and control the concentration The temperature is 40°C, the vacuum degree is 0.1 atmosphere, and when concentrated to 40°C, the relative density is 1.15-1.25. The concentrated solution is left at 0°C for 24 hours to remove the grease layer on the surface of the concentrated solution. Combine the residues, add absolute ethanol to make the alcohol content 50%, put it into an ultrasonic extraction tank, control the temperature at 25°C, extract twice, 15 minutes each time, combine the extracts, and concentrate the ethanol in a rotary wiper to the maximum , control the concentration temperature to 40°C, and the vacuum degree is 0.1 atmosphere to obtain the concentrate;

[0096] (2) Get the above-mentioned concentrated solution on ...

Embodiment 2

[0101] (1) Take 632 grams of Sala seeds, crush them, put them into an ultrasonic extraction tank, control the extraction temperature at 50°C, extract 4 times, each time for 15 minutes, the residue is set aside, combine the extracts, concentrate in a rotary scraping device, and control the concentration The temperature is 50°C, the vacuum degree is 0.2 atmospheres, and the relative density is 1.15-1.25 when concentrated to 50°C. The concentrated solution is left at 4°C for 48 hours to remove the grease layer on the surface of the concentrated liquid. Combine the residues, add absolute ethanol to make the alcohol content 70%, put it into an ultrasonic extraction tank, control the temperature at 50°C, extract 4 times, each time for 45 minutes, combine the extracts, and concentrate the ethanol in a rotary wiper to the maximum , control the concentration temperature to 50°C, and the degree of vacuum to be 0.2 atmospheres to obtain the concentrate;

[0102] (2) Get the above-mention...

Embodiment 3

[0107] (1) Take 571 grams of Sala seeds, crush them, put them into an ultrasonic extraction tank, control the extraction temperature at 40°C, extract 3 times, each time for 10 minutes, and reserve the residue, combine the extracts, concentrate in a rotary scraper, and control the concentration The temperature is 45°C, the vacuum degree is 0.15 atmospheres, and when concentrated to 45°C, the relative density is 1.20. The concentrated solution is left at 2°C for 36 hours to remove the grease layer on the surface of the concentrated solution, and the concentrated solution from which the grease layer has been removed is combined with the residue , add absolute ethanol to make the alcohol content 60%, put it into an ultrasonic extraction tank, control the temperature at 40°C, extract 3 times, each time for 30 minutes, combine the extracts, concentrate the ethanol in a rotary scraper to the end, control The concentration temperature is 45°C, and the vacuum degree is 0.15 atmospheres ...

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Abstract

The present invention discloses a kind of aescin oral disintegrant tablet and its preparation process. The aescine oral disintegrant tablet is prepared with aescin extracted from seed of Chinese buckeye as a kind of Chinese medicinal material and medicinal supplementary material, including disintegrating agent, filler and lubricant in proper contents. The extracted aescin has beta-aescin content controlled in 50-85 wt%. Pharmacological experiment shows that the aescin oral disintegrant tablet has fast disintegrating, quick acting and high pharmacological effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a escin orally disintegrating tablet and a preparation method thereof. Background technique [0002] Salazi is the fruit or seed of Aesculus Aesculus, Aesculus aesculus, Chinese chestnut, and its ineffective components are fatty oil, starch, fiber, etc. The fatty oil is mainly glycerin of oleic acid and stearic acid Ester; its active ingredient is aescin, which belongs to triterpenoid saponin compound. It has anti-inflammatory, anti-exudation, restores capillary permeability, improves venous tension, improves blood circulation, expands arteries, expands coronary arteries, increases resistance Hypoxic ability, promoting the recovery of brain function, etc., the clinical application is mainly its sodium salt, that is, sodium aescinate for injection, but in clinical application, there are a large number of serious adverse reactions: 1. Cause...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K31/704A61K9/20A61P29/00A61P9/10
Inventor 张晴龙
Owner 张晴龙
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