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Medical chitosan dressing and its application

A technology of chitosan and chitosan derivatives, applied in medical science, bandages, absorbent pads, etc., can solve problems such as poor adhesion, achieve good adhesion, promote wound healing, and simple preparation process

Active Publication Date: 2007-01-03
青岛博益特生物材料股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the hemostatic agents used in combination are coagulation factors or sodium alginate or collagen, and these water-insoluble chitosan membranes or sponges made of this have poor adhesion to skin tissue, so it still needs to be further improved and improved. Hemostatic effect and adhesion to skin tissue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1: the preparation of medical chitosan dressing A

[0008] (1) Preparation of Baiji polysaccharide: take 50g of Baiji, a traditional Chinese medicine, and grind it finely, according to "Chinese Medicine Modernization Research and Clinical Application" (Yin Jian, editor-in-chief, Traditional Chinese Medicine Ancient Books Publishing House, 1995) Volume (2), page 120 According to the method described in "Preparation of Baiji Gum", Baiji polysaccharide was prepared to obtain 6 g of Baiji polysaccharide powder. The quality of the traditional Chinese medicine Baiji described in this example meets the quality standard described under "Baiji" on page 67-68 of the 2005 Pharmacopoeia of the People's Republic of China.

[0009] (2) Preparation of chitosan white and glue: take chitosan powder 4g, put in 500ml clean beaker, add 1% (V / V, the same below) acetic acid aqueous solution 150ml, stir and dissolve, get chitosan Aqueous solution of acetic acid. Weigh 0.5 g of th...

Embodiment 2

[0014] Embodiment 2: the preparation of medical chitosan dressing B

[0015] (1) Preparation of chitosan hydroxypropyl chitin glue: Weigh 4.0 g of chitosan powder, put in a 500 ml clean beaker, add 150 ml of 1% acetic acid aqueous solution, stir and dissolve to obtain chitosan acetic acid aqueous solution. Weigh 1.0g of hydroxypropyl chitin powder, put it into another 100ml clean beaker, add 50ml of 1% acetic acid aqueous solution, stir and dissolve to obtain hydroxypropyl chitin acetic acid aqueous solution. The chitosan acetic acid aqueous solution and the hydroxypropyl chitin acetic acid aqueous solution are combined and stirred evenly to obtain chitosan hydroxypropyl chitin glue.

[0016] (2) Preparation of membranous chitosan dressing B: get 60ml of the above-mentioned chitosan hydroxypropyl chitin glue, prepare membranous chitosan dressing B according to the step of (3) of Example 1, and obtain membranous shell Glycan Dressing B.

[0017] (3) Preparation of spongy chit...

Embodiment 3

[0020] Embodiment 3: the preparation of medical chitosan dressing C

[0021] (1) Preparation of chitosan zinc: take chitosan powder 10g, place in a 250ml clean beaker, add 150ml of deionized water, stir and suspend, slowly add 0.2g zinc acetate under stirring, stir at room temperature for 30min, filter, Obtain solid I. The solid I was washed 3 times with 150 ml of deionized water for 20 minutes each time, and filtered to obtain the solid II. Dry the solid II at 60-70°C to obtain chitosan zinc powder.

[0022] (2) Preparation of powdery chitosan dressing C: Weigh 4 g of the above-mentioned chitosan zinc powder, put it in a mortar, and grind it finely to obtain powdery chitosan dressing C.

[0023] (3) Preparation of film-like chitosan dressing C: take by weighing the above-mentioned chitosan zinc powder 2g, put in a 250ml beaker, add 2% acetic acid aqueous solution 100ml, stir and dissolve to obtain chitosan zinc colloidal solution, according to the embodiment The step of (3...

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PUM

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Abstract

The medical chitosan dressing is mixture of chitosan in 1 weight portion, Chinese medicine extract in 0.01-10 weight portions, chitosan derivative in 0.01-10 weight portions, and metal ion in 0.0001-0.05 weight portion. The Chinese medicine extract is bletilla tuber polysaccharide or natural indigo; and the chitosan derivative is one of hydroxypropyl chitin, hydroxypropyl chitosan, succinyl chitin, succinyl chitosan, carboxymethyl chitin and carboxymethyl chitosan. The medical chitosan dressing has the functions of promoting healing of the wound and stopping bleeding, inhibiting bacterial growth, and has excellent wound pasting performance.

Description

technical field [0001] The invention relates to a medical chitosan dressing, in particular to a medical chitosan dressing and its application in wound hemostasis, antibacterial and wound repair. Background technique [0002] Chitosan is a natural macromolecular polycation polysaccharide with good biocompatibility, no immunogenicity, no toxic side effects, hemostatic, antibacterial, anti-infection, and can promote wound healing, easy to form gel and make Film-forming sheets, which endow chitosan with good performance as hemostatic dressings, antibacterial dressings, and wound repair dressings. It has been reported that chitosan is used as a raw material to prepare wound hemostatic materials, antibacterial materials, and materials that promote wound healing. In these studies, chitosan is usually made into a water-insoluble membrane or sponge for hemostasis of wounds and the like. However, due to the limited hemostatic effect of chitosan itself, its hemostatic effect is not i...

Claims

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Application Information

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IPC IPC(8): A61L15/26
Inventor 顾其胜刘万顺韩宝芹
Owner 青岛博益特生物材料股份有限公司
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