Composition of leukotrienes antagonist oral liquid
An oral liquid and anti-allergic technology, which can be used in drug combinations, active ingredients of heterocyclic compounds, allergic diseases, etc., and can solve problems such as difficulty in swallowing pills
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Embodiment 1
[0031] Dissolve Montelukast sodium salt in propylene glycol, dissolve dipotassium hydrogen phosphate, potassium dihydrogen phosphate, sodium saccharin, sodium benzoate, food coloring and spices in water, adjust the concentration of the aqueous solution with 1N sodium hydroxide aqueous solution pH value to pH 9-10. After mixing the aqueous phase and the organic phase, the pH value of the solution was adjusted to pH 9-10 with 1N aqueous sodium hydroxide solution, and the concentration of Montelukast sodium salt was 0.2% w / v, which was completely dissolved. Stability tests were performed at 40°C and 60°C, respectively. After storage at 40°C for 150 days, the concentration of Montelukast sodium salt in the solution did not change; after storage at 60°C for 120 days, the concentration of Montelukast sodium salt in the solution did not change either.
[0032] The concentration of the phosphate-containing component in the aqueous solution is about 0.5-7% w / v. The concentration of t...
Embodiment 2
[0034] Dissolve Montelukast sodium salt in propylene glycol, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, sodium saccharin, sodium benzoate, Tween 80, food coloring and spices in water, and add 1N sodium hydroxide Aqueous solution Adjust the pH value of the aqueous solution to pH 9-10. After mixing the aqueous phase and the organic phase, the pH value of the solution was adjusted to pH 9-10 with 1N aqueous sodium hydroxide solution, and the concentration of Montelukast sodium salt was 0.2% w / v, which was completely dissolved. Stability tests were performed at 40°C and 60°C, respectively. After storage at 40°C for 150 days, the concentration of Montelukast sodium salt in the solution did not change; after storage at 60°C for 120 days, the concentration of Montelukast sodium salt in the solution did not change either.
[0035] The concentration of the phosphate-containing component in the aqueous solution is about 0.5-7% w / v. In this embodiment, the concentr...
Embodiment 3
[0037] Dissolve Montelukast sodium salt in propylene glycol, dissolve boric acid, potassium chloride, saccharin sodium salt, sodium benzoate, food coloring and spices in water, and adjust the pH value of the aqueous solution to pH 9-10. After mixing the aqueous phase and the organic phase, the pH value of the solution was adjusted to pH 9-10 with 1N aqueous sodium hydroxide solution, and the concentration of Montelukast sodium salt was 0.1% w / v, which was completely dissolved. Stability tests were performed at 40°C and 60°C, respectively. After storage at 40°C for 45 days, the concentration of Montelukast sodium salt in the solution did not change; after storage at 60°C for 45 days, the concentration of Montelukast sodium salt in the solution did not change either.
[0038] The concentration of the borate-containing component in the aqueous solution is about 0.1-3% w / v. The concentration of the borate-containing component in this example is about 0.31% w / v. And the consumpt...
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