Drop pills of silymarin, and preparation method

Abstract

A dripping pill of silymarin for treating chronic metastatic hepatitis features high natural level and safety and low toxic by-effect. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine for treating chronic persistent hepatitis prepared from traditional Chinese medicines. Background technique [0002] Silymarn (Silymarn) is a loose powder obtained by extracting and refining the fruit of Silybum marianum (L)Gaertn, a plant of the Compositae family. It has a slightly bitter taste, hygroscopicity, insoluble in water, and has obvious protection and stability. Liver cell membrane function; it has different degrees of protective and therapeutic effects on various types of liver damage caused by carbon tetrachloride, acetamide sulfide, muscarine, hyostigmine, etc. Elevation of alanine aminotransferase has a certain blocking effect. It is clinically used in the treatment of chronic persistent hepatitis, chronic active hepatitis, early liver cirrhosis, liver poisoning and other diseases, and it can significantly improve the symptoms, si...

AI Technical Summary

Problems solved by technology

[0003] Currently on the market are silymarin tablets, Yiganling tablets and Liganlong tablets produced by the German MADAUS pharmaceutical factory. Since silymarin is insoluble in water and has strong hydrophobicity, the silymarin tablets, Yiganling tablets and Liganlong tablets are Low dissolution rate and dissolution rate, poor absorption, low bioavailability, large proportion of excipients, inconvenient administration and poor compliance for children, the elderly, bedridden patients and patients with dysphagia, which affect the therapeutic effect of silymarin

Application number: 03159118.3, application date: 2003.9.8, applicant: Nanchang Hongyi Technology Co., Ltd., invention name: silymarin dripping pills and its preparation method; application number: 03112181.0, application date: 2003.04.21, application (patent right) Person: Shandong Provincial Academy of Traditional Chinese Medicine, name of invention: a drug for treating acute and chronic hepatitis and its preparation process. The drop pill medicine for poisoning and other diseases also provides a preparation method. The drop pill medicine uses polyethylene glycol and other auxiliary materials to make silymarin into drop pills; although the drop pill overcomes the defects of the current tablet and accelerates the dissolution rate, the drop pill Pills have the defect that the natural degree of excipients used is not high

[0004] With the global expansion of the market and the requirement of human beings to return to nature, the use of drugs with low toxicity and side effects, especially pure natural drugs, has become the first choice of people. The preparation is a kind of high-efficiency, quick-acting new Chinese medicine preparation, which overcomes the shortcomings and deficiencies of the previous Chinese medicine preparations, but the current drop pill preparations generally face the following problems: 1. The natural degree of drop pill auxiliary materials is not high: at present, the drop pill matrix Most of the excipients are chemical synthetic products with a low degree of naturalness. It is very difficult to find new alternative matrix excipients, especially the search for alternative matrix excipients with a high degree of naturalness and the determination of their preparation process, because currently common and possible The preparation conditions required for the substitutes of natural matrix excipients are very harsh, and the temperature of excipients and the droplet dripping conditions are the key factors affecting the preparation of droplet pills

If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work

2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been