Preparation method of 4-aminobenzoyl-N-(4-aminobenzoyl) amine

Abstract

A process for preparing 4-aminobenzoyl-N-(4-aminobenzoyl) amine includes such steps as dissolving nitrobenzoyl chloride in organic solvent, adding it to ammonia water, ammonolysis reaction to obtain p-nitrobenzoylamine, iron powder reducing reaction or hydrocatalytic nitro reducing reaction in alcohol-water solution to obtain p-amino benzoylamine, condensating reaction on p-nitrobenzoyl chloride in organic solvent under existence of acid binding agent to obtain 4-nitrobenzoyl-N-(4-aminobenzoyl) amine, and iron powder reducing reaction of hydrocatalytic nitro reducing reaction in solvent.

Description

technical field [0001] The invention belongs to the technical field of compound preparation methods, in particular to a preparation method of 4-aminobenzoyl-N-(4-aminobenzoyl)amine. Background technique [0002] 4-Aminobenzoyl-N-(4-aminobenzamide) amine is an organic pigment intermediate, the main purpose is to synthesize organic pigment yellow C.I 181#. Organic Pigment Yellow C.I 181# is a high-grade organic pigment with very good properties. The most important raw material in its synthesis is 4-aminophenoyl-N-(4-aminophenoyl)amine. So far, only a few countries such as Germany and the United States have industrialized production of this product in the world, while my country has not yet had a production enterprise of this product, and the use of this product in our country still relies on foreign imports. In the investigation of relevant enterprises, it was found that the difficulty in producing organic pigment yellow C.I 181# mainly focused on ...

AI Technical Summary

Problems solved by technology

In the investigation of relevant enterprises, it was found that the difficulty in producing organic pigment yellow C.I 181# mainly focused on the synthesis of its intermediate 4-aminobenzoyl-N-(4-aminobenzamide)amine. The problem is, first: the synthetic intermediate is difficult to meet the quality requirements required for the synthesis of the final product; second: the manufacturing cost of the intermediate is too high, making it difficult for the final product to meet the needs of market competition

There are few reports on the synthesis of 4-aminobenzoyl-N-(4-aminobenzamide) amide in relevant literature, and only a synthetic literature about organic pigment yellow 181# in DE2.845.947 is included in American Chemical Abstracts, while There is also only one related report (Synth.Commun; EN32, 8 2002) in Beil., although the synthetic method adopted in it has achieved satisfactory results in yield and product quality, but the catalyst loading he adopted Hydrogenation complicates the process and increases the cost accordingly