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Herbal composition for treatment of arthritic disorders, skin inflammatory disorders and pain

A technology for arthritis and composition, applied in the field of herbal extracts, can solve problems such as undisclosed andrographolide

Inactive Publication Date: 2006-11-22
云南白药中草药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, the prior art literature does not reveal at all that andrographolide or andrographolide itself can be used in the treatment of arthritic conditions (especially arthritis)

Method used

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  • Herbal composition for treatment of arthritic disorders, skin inflammatory disorders and pain
  • Herbal composition for treatment of arthritic disorders, skin inflammatory disorders and pain
  • Herbal composition for treatment of arthritic disorders, skin inflammatory disorders and pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1. Standardization of herbal medicine quality control

[0037] High performance liquid chromatography (HPLC) was used to determine the quality of each batch of Andrographis paniculata herb. The HPLC method and test results are described as follows:

[0038] (a) Preparation of herbal extracts for HPLC analysis

[0039] Accurately weigh 50 g of herbal medicine, place it into a 1000 ml sample bottle, and then add 500 ml of distilled water. The resulting mixture was blended at room temperature and 1000 rpm for 5 minutes, then heated at 100°C for 2 hours. After filtering the mixture through a 60-mesh microfiltration membrane, 1 ml of the extract was taken and diluted with distilled water to a total volume of 50 ml. The 1 ml extract was filtered through a 0.45 μM filter before HPLC analysis.

[0040] (b) HPLC analysis

[0041] time (minutes)

water%

Acetonitrile%

linear

0

100

0

*

5

70

30

lin...

Embodiment 2

[0044] Embodiment 2. The method for preparing herbal composition

[0045] The method for preparing the herbal composition of the present invention is shown in figure 2 in the flow chart. Specifically, the aerial part (100 kg) of Andrographis paniculata was added to 1500 L of deionized water containing 5 to 15% ethanol at room temperature, and the mixture was heated at 100° C. for 2 hours. The obtained extract was decanted and passed through a 120 μm nylon mesh, and then stored in a 32000 L stainless steel container. The extraction of the insoluble solid residue was repeated with an additional 1500 L of deionized water under the same conditions as above. The resulting 2nd extract was added to the 1st extract and pooled to produce a total of approximately 2950 L of extract. After concentrating under reduced pressure, the total volume of the extract was reduced to 50±5L, then 8.5±0.5kg of cornstarch was added and fully stirred. At -25°C and 6kg / cm 3 Freeze drying was carrie...

Embodiment 3

[0046] Example 3. Screening on Herbal Chips

[0047] A high throughput method for the discovery of active ingredients in herbal medicines has been described in the specification USP 6,645,719. Its method is described as follows:

[0048] (a) Fractionation of herbal extracts by HPLC

[0049] The dried Andrographis paniculata herb was ground to a fine powder and extracted with methanol, ethanol or distilled water at a ratio of 50 g of ground powder / 500 ml of HPLC grade solvent at 25 to 30°C. Extraction was performed using a homogenizer (OMNI) with continuous blending for 5 minutes. Then centrifuge at 8000 rpm (Beckman) for 30 minutes, and repeat the treatment of the residue (ie, sediment) twice using the same method as above. The clear supernatant of the herbal extract was collected and then concentrated to a final volume of 30 ml using a rotary evaporator (Laborota 4000, HEIDOLPH). The volume of the concentrated extract was increased to 50 ml with a mixture of 50% water and...

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PUM

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Abstract

The present invention provides a method for treating arthritic disorders, skin inflammatory disorders and pain, comprising administering to a subject an extract of Andrographis paniculata Nees, and also provides a herbal composition used therefor that comprises the extract of Andrographis paniculata Nees.

Description

technical field [0001] The present invention relates to a herbal extract for the treatment of arthritis conditions, skin inflammation conditions and pain. The herbal extract acts as a tumor necrosis factor (TNFα) antagonist. In particular, the herb is Andrographis paniculata Nees. Background technique [0002] Arthritic conditions include osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), gout, spondylosis (AS), and other joint disorders. All arthritic conditions are characterized by inflammation and pain, and most arthritic conditions are progressive. So far, neither the pathogenic cause of arthritic conditions nor its mechanism of action is known. [0003] Prostaglandins have been identified as responsible for causing inflammation and thus pain. The release of prostaglandins has been triggered by cyclooxygenase-2 (Cox-2), which is an isoform of cyclooxygenase-1 (Cox-1) and which inducibly expresses Various pro-inflammatory stimuli res...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/19A61K9/00A61K9/14A61K9/20A61K9/48A61P17/00A61P17/06A61P19/02A61P25/04
CPCA61K36/19A61P17/00A61P17/06A61P19/02A61P25/04
Inventor 徐立伟张素真庄国昇林轩仪陈志雄
Owner 云南白药中草药科技有限公司
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