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Medicine composition for treating hepatitis

A composition and drug technology, applied in the direction of drug combination, active ingredients of heterocyclic compounds, digestive system, etc., can solve problems such as difficult to obtain and eradicate HBV

Inactive Publication Date: 2006-11-08
SINOPHARM A THINK PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the replication of HBV in the body is a complex process, and it is difficult to achieve the effect of eradicating HBV with a single drug. Only by inhibiting the replication of HBV at multiple target sites can a good therapeutic effect be achieved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 1:1 composition of oxymatrine and ganciclovir

[0019] Mix equal amounts of oxymatrine and ganciclovir to obtain pharmaceutical composition 1. The composition 1 was prepared into the following various dosage forms.

[0020] 1-1. Preparation of injection

[0021] Take equal amounts of oxymatrine and ganciclovir and mix 200g each, add water for injection, and adjust the pH to 10-12 with sodium hydroxide to make a mixed solution containing 100mg oxymatrine and ganciclovir per ml. Add activated carbon for needles, stir for 10 minutes, place for 30 minutes, filter and decarburize, fill the semi-finished solution after passing the test, and fill it with 2ml each.

[0022] 1-2. Preparation of tablets

[0023] Take the equal amount of oxymatrine and ganciclovir each 200g and mix, add 150g of microcrystalline cellulose, granulate with 50ml of 10% PVP k-30 (50% ethanol solution), dry, size, weigh the granules, Add carboxymethyl starch sodium according to 4% weight of the gr...

Embodiment 2

[0034] Example 2 1:2 composition of oxymatrine and ganciclovir

[0035] 2-1. Preparation of injection

[0036] Take 100g of oxymatrine and 200g of ganciclovir and mix, add water for injection, and adjust the pH to 10-12 with sodium hydroxide solution to make a mixed solution containing 100mg of oxymatrine and 200mg of ganciclovir per ml , Add activated carbon for needles, stir for 10 minutes, place for 30 minutes, filter and decarburize, fill the semi-finished product solution after passing the test, and fill it with 2ml each.

[0037] 2-2. Preparation of tablets

[0038] Take 100g of oxymatrine and 200g of ganciclovir and mix, add 200g of microcrystalline cellulose, granulate with 100ml of 10% PVP k-30 (50% ethanol solution), dry, size, weigh the granules, press Add carboxymethyl starch sodium to 6% by weight of the granules, and add magnesium stearate to 2% by weight of the granules to compress and coat to prepare tablets.

[0039] 2-3. Preparation of capsules

[0040] Take 100g...

Embodiment 3

[0049] Example 3 2:1 composition of oxymatrine and ganciclovir

[0050] Oxymatrine and ganciclovir were mixed in a ratio of 2:1 to obtain composition 3. Take 200 g of oxymatrine and 100 g of ganciclovir according to the method of Example 1.

[0051] 3-1. Preparation of injection

[0052] Mix 200 g of oxymatrine and 100 g of ganciclovir, add water for injection, and adjust the pH to 10-12 with sodium hydroxide solution to prepare a mixed solution containing 200 mg of oxymatrine and 100 mg of ganciclovir per ml , Add activated carbon for needles, stir for 10 minutes, place for 30 minutes, filter and decarburize, fill the semi-finished product solution after passing the test, and fill it with 2ml each

[0053] 3-2. Preparation of tablets

[0054] Take 200 g of oxymatrine and 100 g of ganciclovir and mix, add 50 g of microcrystalline cellulose, granulate with 30 ml of 10% PVP k-30 (50% ethanol solution), dry, sizing, weigh the granules, and press 2% by weight of the granules are added...

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PUM

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Abstract

The present invention relates to hepatitis treating medicine composition, and especially hepatitis treating lovir medicine composition. The lovir medicine composition contains lovir compound in 10-50 weight portions and Chinese medicine component matrine in 10-50 weight portions. The lovir compound and the matrine component result in excellent synergistic antiviral effect and less side effects, so that the lovir medicine composition has raised curative effect and lowered toxicity.

Description

Technical field [0001] The invention relates to a medicinal composition for treating hepatitis, in particular to a lovir-like medicinal composition for treating hepatitis. Background technique [0002] Lovir drugs are nucleoside analogs, which can competitively inhibit viral DNA polymerase, directly incorporate viral DNA, and stop the elongation of viral DNA. It is a class of antiviral hepatitis drugs with very obvious effects. However, there are certain adverse reactions in such drugs, which restricts the use of such drugs. After taking this kind of drug, it is prone to severe rebound phenomenon, which makes the disease repeated, which leads to the tolerance of the virus to the drug, and can lead to neutropenia and thrombocytopenia. At the same time, the drug still exists It has certain nephrotoxicity and neurotoxicity. [Adverse Reactions of Acyclovir, Journal of Adverse Drug Reactions, Issue 1, 2004] [Adverse Reactions of Ganciclovir, Journal of Adverse Drug Reactions, Issue 5,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61P1/16A61P31/20
Inventor 王振国贾志丹曹树煜吴素林
Owner SINOPHARM A THINK PHARMA
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