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Production method for extracting chenodeoxycholic acid using chicken gall

A technique for chenodeoxycholic acid and a production method is applied in the field of chenodeoxycholic acid extraction from chicken gall bladder, and can solve the problems of high production cost, low chenodeoxycholic acid purity, complicated chenodeoxycholic acid production process, and the like, To achieve the effect of simple process, improved product purity and low production cost

Inactive Publication Date: 2010-04-14
辽宁百隆生物工程有限公司
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Problems solved by technology

[0003] The currently known production process of chenodeoxycholic acid is very complicated, and the production cost is high, especially the purity of chenodeoxycholic acid is low, which affects product quality and medical efficacy

Method used

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Embodiment Construction

[0014] The production method of extracting chenodeoxycholic acid with chicken bile is:

[0015] Take fresh frozen chicken gall, cut it into 10mm slices, put it into a reaction kettle, heat it to 70°C, cook for 1 hour, separate the bile, add sodium hydroxide accounting for 10% of the total amount of bile, heat to 100°C, and boil for 24 hours , reflux, after cooling, adjust the pH value to pH 2 with hydrochloric acid to obtain a brown-black paste, wash with water until neutral, add brown-black gall paste, add 2 times the amount of 95% ethanol, and then add 10% of the weight of the brown-black paste diatomite, after reflux for 30 minutes, add 10% activated carbon of the weight of the brown-black paste, reflux for 2 hours, let cool and filter, add the filtrate to an equivalent amount of 120# gasoline to degrease, reflux for 2 hours, and let it stand After 30 minutes, the ethanol solution was separated after layering, and the ethanol solution was evaporated to dryness. Barium and ...

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Abstract

The feature of the invention includes: adopting frozen chicken gallbladder slicing, heating to 70 degree centigrade, adding 10% weight of the bile boiling for 24 hours, reflux cooling, adjusting the pH value by hydrochloric acid to gain cream, washing to neutrality; adding 95% alcohol and 10% diatomite, reflux cooling and adding active carbon, reflux, cooling and filtering, adding petrol to the filtrate to take degreasing, reflux, standing, separating alcohol liquid and washing to neutrality in reaction kettle, adding 95% alcohol, after resolving, adding barium chloride and active carbon, reflux, hot filtering, concentrating white crystal from the filtrate, washing, and adding water and sodium carbonate water solution, heating and reflux, filtering, adjusting the pH value, drying. The invention has simple technology, low cost, and could drastically separate cholesterol, lithocholic acid, and cholic acid from gall, and improves the purity.

Description

(1) Technical field [0001] The invention relates to a preparation method of a medicine for treating gallstones, in particular to a method for extracting chenodeoxycholic acid from chicken bile. (2) Background technology [0002] Chenodeoxycholic acid, chemical name: 3α,7α,-dioxo-5β-cholanic acid. The traits are colorless needle-like crystals, odorless, not easily soluble in water. Chenodeoxycholic acid can directly expand the bile acid pool, prevent cholesterol from being supersaturated, limit the activity of hydroxy-methylglutaryl coenzyme, reduce the synthesis and secretion of cholesterol, so as to prevent and dissolve cholesterol stones, and it is also effective for mixed stones. Certain effect. It can also be used as a raw material for the synthesis of ursodeoxycholic acid. [0003] The currently known production process of chenodeoxycholic acid is very complicated and the production cost is high, especially the purity of chenodeoxycholic acid is low, which affects pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00A61K35/413
Inventor 姚凤云
Owner 辽宁百隆生物工程有限公司
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