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Micro-powder dom peridone maleate medicinal composition and its preparing method

A technique for domperidone maleate and its composition, applied in the field of micronized domperidone maleate pharmaceutical composition and its preparation, capable of solving the problems of low bioavailability of domperidone

Active Publication Date: 2006-10-25
NANJING CHANGAO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above methods may improve the dissolution rate and bioavailability of domperidone, but do not fundamentally solve the problem of low bioavailability of domperidone

Method used

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  • Micro-powder dom peridone maleate medicinal composition and its preparing method
  • Micro-powder dom peridone maleate medicinal composition and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Micronized Domperidone Maleate 20g

[0021] polysorbate 80 2g

[0022] Microcrystalline Cellulose 20g

[0023] Lactose 40g

[0024] Povidone K30 0.1g

[0025] Micronized silica gel 0.1g

[0026] Mix micronized domperidone maleate, polysorbate 80, microcrystalline cellulose, and lactose with a V-shaped mixer, directly add povidone K30 (wetting agent) to the mixed powder, and mix the obtained soft The materials were granulated with a swinging granulator, dried in an oven, compressed into tablets, and coated with Opadry(R) in water using a high-efficiency coating pan.

Embodiment 2

[0028] Co-micronized domperidone maleate and polysorbate 80 22g

[0029] Microcrystalline Cellulose 20g

[0030] Lactose 40g

[0031] Povidone K30 0.1g

[0032] Micronized silica gel 0.1g

[0033] Domperidone maleate and polysorbate 80 are co-micronized, then mixed with microcrystalline cellulose and lactose with a V-type mixer, and povidone K30 (wetting agent) is directly added to the mixed powder, The obtained soft material is granulated with a swing granulator, then dried in an oven, compressed into tablets, and coated with Opadry(R) in water using a high-efficiency coating pan.

Embodiment 3

[0035] Micronized Domperidone Maleate 20g

[0036] polysorbate 80 5g

[0037] Microcrystalline Cellulose 20g

[0038] Lactose 50g

[0039] Povidone K30 0.2g

[0040] Micronized silica gel 0.4g

[0041] Mix micronized domperidone maleate, polysorbate 80, microcrystalline cellulose, and lactose with a V-shaped mixer, directly add povidone K30 (wetting agent) to the mixed powder, and mix the obtained soft The materials were granulated with a swinging granulator, then dried in an oven, mixed with talcum powder and then compressed into tablets, and then coated with Opadry® in water using a high-efficiency coating pan.

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Abstract

The present invention relates to a medicine composition with domperidone maleate. It is characterized by that said medicine composition is micropowdered, and can be used for invigorating function of gastrointestinal tract and curing the diseases of dyspepsia and nausea-vomiting, etc. Said micropowdered domperidone maleate preparation can raise its bioavailability. Besides, said invention also provides its preparation method.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing micronized domperidone maleate (Domperidone Maleate). Background technique [0002] Domperidone is a peripheral dopamine receptor blocker, acting directly on the gastrointestinal wall, increasing the tension of the lower esophageal sphincter, preventing gastroesophageal reflux, enhancing gastric motility, promoting gastric emptying, coordinating gastric and duodenal motility, inhibiting Nausea, vomiting, and can effectively prevent bile reflux without affecting gastric secretion. It is clinically used to relieve dyspepsia symptoms caused by delayed gastric emptying, gastrointestinal reflux, and esophagitis, such as: upper abdominal distension, abdominal distension, upper abdominal pain, belching, flatulence, with or without Heartburn with regurgitation of stomach contents. Nausea and vomiting caused by functional, organic, infectious, diet, radiation therapy or chemotherapy. ...

Claims

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Application Information

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IPC IPC(8): A61K31/454A61K9/20A61P1/08A61P1/14
Inventor 李战张自强晁阳黄海燕
Owner NANJING CHANGAO PHARM CO LTD
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