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'Xindakang' dispersion tablets and prepn. method

A technology of dispersible tablet and Xindakang, which is applied in the field of Xindakang dispersible tablet and its preparation, can solve the problems of poor solubility of acetosal flavonoids, increased absorption speed and bioavailability of acetosal flavonoids, long disintegration time and the like

Active Publication Date: 2006-09-20
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Based on the good clinical basis of Xindakang Tablets and the current shortcomings, the purpose of the present invention is to provide a new pharmaceutical preparation and its preparation method, which has a longer disintegration time and a slower onset time for ordinary tablets. Low bioavailability, poor solubility of acetaloflavone in water and other deficiencies, making it into a dispersible tablet with the reputation of solid oral liquid not only greatly increases its solubility, but also quickly disintegrates in cold water to form a uniform The suspension can be drunk directly, swallowed directly or sublingually contained, which is convenient to take; at the same time, it increases the surface area, releases the drug quickly, increases the absorption speed and bioavailability of acetaloflavone, and plays a quick-acting and high-efficiency effect effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: flavanone 50g low-substituted hydroxypropyl cellulose 45g calcium sulfate 55g

[0026] The acetaloflavone and the auxiliary materials in the prescription are respectively pulverized into fine powders, mixed evenly by the method of increasing in equal amount, granulated with 60% ethanol in an appropriate amount, dried, and pressed into 1000 tablets to obtain the final product.

Embodiment 2

[0027] Embodiment 2: acetaloflavone 50g sodium carboxymethyl starch 37g lactose 63g

[0028] The acetaloflavone and the auxiliary materials in the prescription are respectively pulverized into fine powders, mixed evenly by the method of increasing in equal amount, granulated with 60% ethanol in an appropriate amount, dried, and pressed into 1000 tablets to obtain the final product.

Embodiment 3

[0029] Embodiment 3: 50 g of acetaloflavone, 37 g of cross-linked polyvinyl pyrrolidone, and 63 g of pregelatinized starch

[0030] The acetaloflavone and the auxiliary materials in the prescription are respectively pulverized into fine powders, mixed evenly by the method of increasing in equal amount, granulated with 60% ethanol in an appropriate amount, dried, and pressed into 1000 tablets to obtain the final product.

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PUM

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Abstract

A dispersing tablet of Xindakang with high solubility and disintegrating speed for treating ischemic heart disease, arrhythmia, hypertension, hyperlipemia, hyperviscosity blood, etc is prepared from flavone acetylsalicylate and proper additive. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a Xindakang dispersible tablet for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. technical background [0002] Cardiovascular and cerebrovascular diseases have become the number one killer threatening human health, with the characteristics of high morbidity, high mortality, and high disability rate. According to reports, 2.6 million people die from cardiovascular and cerebrovascular diseases in my country every year, and one person dies from such diseases every 12 seconds. Therefore, the prevention and treatment of cardiovascular and cerebrovascular diseases has become an important task for medical experts, scholars and enterprises. serious and difficult subject. In this tough battle, acetaloflavone and its preparations have attracted more and more attention and favor from the world. Modern pharmacological studies have sh...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K36/48A61K9/20A61P9/06A61P9/10A61P9/12A61P3/06
Inventor 张保献
Owner BEIJING INCREASEPHARM CORP LTD
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