Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

New pranoprofen eye drops and its preparation method

A technology of eye drops and liquid medicine, which is applied in the field of medicine, can solve the problems of unseen pranoprofen eye drops and achieve stable and reliable storage

Active Publication Date: 2006-08-30
JIANGSU JIBEIER PHARMA
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Domestic pranoprofen eye drops have been listed, but there is no report of pranoprofen eye drops with sodium hyaluronate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New pranoprofen eye drops and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] prescription:

[0019] Pranoprofen 1g

[0020] Sodium Hyaluronate 1g

[0021] Appropriate amount of related accessories

[0022] Add water for injection to 1000ml

[0023] Preparation method:

[0024] Get pranoprofen and related auxiliary materials and dissolve in appropriate amount of water for injection respectively.

[0025] Take the prescribed sodium hyaluronate in water for injection, stir continuously at 60-70°C to make it fully swell, boil, and filter while hot with a microporous membrane.

[0026] Slowly add the filtered sodium hyaluronate solution into the pranoprofen solution, stir evenly while adding, add water for injection to a sufficient amount, filter to obtain a clear solution, subpackage, and inspect the quality to complete.

Embodiment 2

[0028] prescription:

[0029] Pranoprofen 1g

[0030] Sodium Hyaluronate 1g

[0031] Boric acid 15g

[0032] Appropriate amount of related accessories

[0033] Add water for injection to 1000ml

[0034] Preparation method:

[0035] Get pranoprofen, boric acid and related auxiliary materials and dissolve in appropriate amount of water for injection respectively.

[0036] Take the prescribed sodium hyaluronate in water for injection, stir continuously at 60-70°C to make it fully swell, boil, and filter while hot with a microporous membrane.

[0037] Slowly add the filtered sodium hyaluronate solution into the pranoprofen solution, stir evenly while adding, add water for injection to a sufficient amount, filter to obtain a clear solution, subpackage, and inspect the quality to complete.

Embodiment 3

[0039] prescription:

[0040] Pranoprofen 1g

[0041] Sodium Hyaluronate 2g

[0042] Boric acid 15g

[0043] Appropriate amount of related accessories

[0044] Add water for injection to 1000ml

[0045] Preparation method:

[0046] Get pranoprofen, boric acid and related auxiliary materials and dissolve in appropriate amount of water for injection respectively.

[0047] Take the prescribed sodium hyaluronate in water for injection, stir continuously at 60-70°C to make it fully swell, boil, and filter while hot with a microporous membrane.

[0048] Slowly add the filtered sodium hyaluronate solution into the pranoprofen solution, stir evenly while adding, add water for injection to a sufficient amount, filter to obtain a clear solution, subpackage, and inspect the quality to complete.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A kind of eye-drops of pranoprofen with long stay time in eye and no bitter taste is prepared through dissolving pranoprofen and relative additives in water, adding the aqueous solution of sodium hyaluronate, stirring, adding water, filtering and filling it in containers.

Description

technical field [0001] The invention relates to the technical field of medicine, and discloses a new pranoprofen eye drop and a preparation method thereof. Background technique [0002] Pranoprofen, chemical name: 2-(5H-[1]benzopyran[2,3-b]pyridin-7-yl) propionic acid, structural formula is as follows: [0003] [0004] Prostaglandins have a wide range of local effects on various tissues, especially when inflammatory reactions occur, they can be found in various animals and human bodies, and are relatively important substances in inflammatory reactions. Physical and chemical trauma to the eye, surgery, anterior chamber puncture, laser irradiation, and stimulation of the trigeminal nerve all lead to the synthesis and release of prostaglandins in ocular tissues, resulting in miosis, conjunctival and vasodilation, increased aqueous humor protein content, and increased intraocular pressure. Glucocorticoids are effective drugs to control non-infectious inflammation of the out...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/436A61K9/08A61P27/02
Inventor 张宏业
Owner JIANGSU JIBEIER PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com