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Chuanxiong lactone kind component soft capsule for treating cardiovascular and cerebrovascular diseases

A kind of cardiovascular and cerebrovascular disease and soft capsule technology, which is applied in the field of soft capsules for the treatment of cardiovascular and cerebrovascular diseases with chuanxiong lactones

Inactive Publication Date: 2006-08-30
国家纳米技术产业化基地
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, compared with foreign countries, there are still many gaps in the development and research of appearance, shape, varieties for different uses, product quality and process prescription.

Method used

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  • Chuanxiong lactone kind component soft capsule for treating cardiovascular and cerebrovascular diseases
  • Chuanxiong lactone kind component soft capsule for treating cardiovascular and cerebrovascular diseases
  • Chuanxiong lactone kind component soft capsule for treating cardiovascular and cerebrovascular diseases

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Embodiment 1: Chuanxiong lactone component soft capsule

[0083] The following examples illustrate specific embodiments of the present invention, each component of soft capsule preparation is mixed, glue, batching→soft capsule pill press→fluidized bed soft capsule pre-drying machine→ultrasonic soft capsule cleaning machine

[0084] contents

Embodiment 2

[0085] Embodiment 2: Chuanxiong lactone component soft capsule

[0086] The components of soft capsule preparation are mixed, gelatinized and ingredients→soft capsule pellet machine→fluidized bed soft capsule predrying machine→ultrasonic soft capsule cleaning machine

[0087] Ground feeder→track-type automatic dryer→semi-automatic capsule tablet inspection machine→aluminum-plastic inner and outer packaging

[0088] content

Embodiment 3

[0089] Embodiment 3: biological screening method to study the chuanxiong lactone components through the blood-brain barrier, to achieve the time working curve of the therapeutic effect

[0090] 1. Selection of chromatographic conditions

[0091] HPLC: Column Nova-Pak  C18 (3.9×150mm); mobile phase: methanol-water-acetic acid (35:65:0.5, V / V / V); flow rate 0.8mL / min; UV detection wavelength: 270nm, 320nm; injection volume: 20μL.

[0092] MS: atmospheric pressure chemical ionization (APCI); scan interval: 1.00s; mass range: m / z 100-300; AP+ detection.

[0093] 2. Experimental results

[0094] The HPLC chromatograms of serum, brain homogenate, blank serum, and blank brain plasma were detected at 270nm after gavage of rats for 2 hr. Figure 4 and Figure 5 shown. In serum and brain homogenate, the retention time of the chuanxiong lactone component chromatographic peak corresponds to the retention time of the Chuanxiong standard fingerprint chromatogram component (see appendix...

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Abstract

A soft capsule of cnidium lactone for treating cardiovascular and cerebrovascular diseases is prepared from the active cnidium lactone type components, dispersing medium, plasticizer, disintegrant, coloring agent, optical mask and others.

Description

(1) Technical field: [0001] The invention relates to a lactone soft capsule, in particular to a soft capsule for treating cardiovascular and cerebrovascular diseases with chuanxiong lactone components. (two) background technology: [0002] Capsules can generally be divided into hard capsules, soft capsules and enteric-coated capsules for oral use. Hard capsules are made by making a certain amount of medicine plus auxiliary materials into uniform powder or granules and filling them in hollow capsules, or by directly distributing medicines into hollow capsules. Soft capsules refer to the sealing of a certain amount of liquid medicine in spherical or oval soft capsules, which can be prepared by dripping or pressing. Also known as elastic capsules, it is made of gelatin, glycerin or suitable medicinal materials for capsules. Enteric-coated capsules refer to hard capsules or soft capsules processed with pharmaceutical polymer materials or processed by other appropriate methods....

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K36/236A61K9/48A61P9/10
Inventor 魏海丁明玉杨学东吕琨
Owner 国家纳米技术产业化基地
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