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Chinese medicinal composition for treating tuberculosis and its preparation method

A composition and technology for pulmonary tuberculosis, which can be used in pharmaceutical formulations, drug delivery, medical preparations containing active ingredients, etc., and can solve problems such as side effects, increase in drug resistance cases, and threats to health.

Inactive Publication Date: 2011-06-15
SHENYANG HONGQI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above several western medicines are generally used in combination in the treatment of pulmonary tuberculosis. Although they also have certain therapeutic effects, their toxic and side effects will bring new diseases and misery to patients.
Chemotherapy can alleviate the condition to a certain extent. The initial treatment can excrete 95-100% of bacteria, and the sputum bacteria can be turned negative. However, chemotherapy has certain side effects on the liver, kidney, and gastrointestinal functions of patients, which makes many patients unable to adhere to medication. , long-term irregular medication, resulting in drug resistance of Mycobacterium tuberculosis, increase of drug-resistant cases and long-term lesions unchanged, causing great pain to patients. Therefore, due to the increasing variation of tuberculosis strains and drug resistance
As a result, the effect of the original anti-tuberculosis drugs is obviously not as good as before, and some anti-tuberculosis drugs with better efficacy, such as rifampicin, isoniazid, streptomycin, etc., are significantly less sensitive to Mycobacterium tuberculosis, and have relatively large toxic and side effects; And the patient is difficult to accept long-term chemical treatment, so tuberculosis quietly breeds again, turbulent resurgence, once again threatens the health of human beings

Method used

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  • Chinese medicinal composition for treating tuberculosis and its preparation method

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Effect test

Embodiment 1

[0020] The preparation method of syrup of the present invention:

[0021] Weigh each raw material: 450 grams of garlic, 450 grams of Prunella vulgaris, 400 grams of Polygonum multiflorum, 400 grams of Baibu, 250 grams of Bletilla striata, 250 grams of Rhizoma Polygonatum, decoct in water twice, each time for 1 hour, filter, combine the filtrates, and condense into a thick paste , add ethanol for precipitation twice, so that the alcohol content reaches 65% for the first time, and 80% for the second time, filter, recover ethanol and concentrate to about 700mL, add sucrose and ethylparaben alcohol solution while hot and stir to dissolve , add boiling water to the full amount, stir well and serve.

Embodiment 2

[0023] The preparation method of granule electuary of the present invention:

[0024] Weigh 500 grams of garlic, 500 grams of Prunella vulgaris, 500 grams of Polygonum multiflorum, 300 grams of Baibu, 300 grams of Bletilla striata, and 300 grams of Polygonatum. Grind the above-mentioned medicine into coarse powder, decoct in water for two times, the first time for 2 hours, the second time for 1 hour, filter, the filtrate is concentrated into a thick paste, dried, crushed through a 100-mesh sieve, mixed, moistened, softened, and formed Take out the agglomerates and make granule granules.

Embodiment 3

[0026] (a) Weigh the garlic, Prunella vulgaris, and Polygonum multiflorum with 70% to 95% ethanol for reflux extraction twice, combine the two extracts, recover the ethanol, and dry at 45 to 55°C to obtain a dry extract 1;

[0027] (b) Decoct the residues of Polygonatum, Bletilla striata, Radix Bletillae, Garlic, Prunella vulgaris, and Radix Polygoni Multiflori with alcohol in the weight ratio twice, adding water each time so as not to cover the medicinal noodles, and combining the two decoctions , filtered to obtain filtrate 2, concentrated filtrate into extract with a specific gravity of 1.15 to 1.35, and dried at 45 to 55°C to obtain dry extract 2;

[0028] (c) Combine dry extracts 1 and 2, pulverize it into powder, and prepare the active ingredient of the medicine of the present invention;

[0029] (d) Fully mix the obtained active ingredient with pharmaceutically acceptable additives such as flavoring agents and adjuvants to prepare any pharmaceutical dosage form. If t...

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Abstract

The invention discloses a Chinese medicinal combination for curing pulmonary tuberculosis and the application thereof, composed of garlic, Common Selfheal Fruit-Spike, Tuber Fleeceflower Root, Tuber Stemona Root, Bletilla tuber, King Solomonseal Rhizome, etc. And the preparing method includes the following steps of: weighing all raw materials in proportion, crushing and grinding them into powders, making water decoction or alcoholic extraction twice, 1-2 hours for the first time and 1-1.5 hour for the second time, filtering, concentrating the filtrate into ointment, and able to add in cane sugar and other additives to make syrup or drying secondary ointments made by alcoholic and water extractions, combing the dry ointments, crushing and passing through 100-mesh sieve, mixing uniformly, wetting, softening, forming into a mass and then taking out the mass, and making the mass into granular infusion or other preparations.

Description

technical field [0001] The invention relates to a Chinese patent medicine, in particular to a preparation method and application of a medicine composition for treating pulmonary tuberculosis with Chinese medicine as a main component. Background technique [0002] Tuberculosis is a common and difficult disease, which is a relatively common chronic infectious disease caused by Mycobacterium tuberculosis infection. Tuberculosis can occur in various tissues and organs of the human body, but the lung is the most common, and tuberculosis that occurs in the lung is called pulmonary tuberculosis. The general clinical use of Western medicine and chemotherapy for the treatment of tuberculosis at home and abroad. The western medicine for modern clinical treatment of pulmonary tuberculosis mainly includes isoniazid: its main toxic and side effects are excitability, insomnia, peripheral nerve inflammation, and occasionally liver function damage; rifampicin: its main toxic and side effec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61K9/00A61K9/16A61K9/20A61K9/46A61K9/48A61P31/06
Inventor 杨雄志
Owner SHENYANG HONGQI PHARMA
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