Pharmaceutical composition making pregabalin as active ingredient, its preparation method and uses

Abstract

The invention relates to a medicinal composition with pregabalin as the active constituent, its preparing process and use, which comprises pregabalin as the medicinal active constituent, as well as pharmaceutically acceptable auxiliary materials, The composition can be used for treating peripheral nerve pain and epilepsy, and can be prepared into the forms of tablets, capsules, dispersible tablets, granules, soft capsules, chewable tablets, buccal tablets, buccal tablets or other oral preparations.

Description

technical field [0001] The invention relates to a pharmaceutical composition with pregabalin as an active ingredient, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Epilepsy is a chronic disease in which the sudden abnormal discharge of brain neurons leads to transient brain dysfunction. Due to the different parts involved in the abnormal discharge of neurons, it can be manifested as seizures of motor, sensory, autonomic, conscious and mental disorders. It is one of the common clinical symptoms caused by many reasons. According to the domestic epidemiological survey, its incidence rate is about 1‰ of the population, and its prevalence is about 5‰ of the population. [0003] The chemical name of pregabalin is (3S)-3-(Aminomethyl)-5-methylhexanoic acid and its chemical structure is [0004] [0005] Experiments have found that pregabalin can bind to the α2γ-subunit gabapentin binding site on the...

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[0006] In addition, studies of the drug in the treatment of neuropathic pain have shown that in various mouse models of neuropathic pain, including intrathecal injection of P-or-NMDA neuron receptors, carrageenan and formalin-induced Pain model, pregabalin was at least twice as effective as gabapentin in relieving pain, but had no sedative effect

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