Screen for pre-eclampsia

A preeclampsia, risk technology, applied in the field of preeclampsia screening, can solve problems such as limiting reliable predictive tests

Inactive Publication Date: 2006-07-12
UNIV COLLEGE OF LONDON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, little is known about the pathogenesis of preeclampsia, thus limiting the development of reliable predictive tests and effective preventive methods

Method used

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  • Screen for pre-eclampsia
  • Screen for pre-eclampsia
  • Screen for pre-eclampsia

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Experimental program
Comparison scheme
Effect test

Embodiment

[0086] 1. Method

[0087] research participants

[0088] All women attending routine antenatal care at King's College Hospital underwent color Doppler imaging of the uterine arteries (Acuson Aspen, California, USA) at 23-25 ​​weeks of gestation. Doppler waveforms of the uterine artery were obtained as described above (Albaiges G et al. Obstet Gynecol 2000; 96:559-64). When three similar consecutive waveforms were obtained, an early diastolic notch was noted and the mean pulsatility index (PI) of both vessels was calculated. Forty-three pregnant women with serially identified abnormal uterine artery Doppler waveforms (double early diastolic notch) were recruited at the time of the Doppler study and compared with 43 pregnant women with normal uterine artery Doppler waveforms. Matched for age, race, and smoking status. At the time of enrollment, all women had singleton pregnancies, were healthy, were not taking medication, had no personal or family history of premature cardiov...

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Abstract

It has been demonstrated that the level of asymmetric dimethylarginine (ADMA) increases in women that subsequently develop pre-eclampsia or whose fetus subsequently develops intrauterine growth restriction (IUGR) and that ADMA plays a key role in the development of maternal hypertension. Accordingly, the level of ADMA in a pregnant woman can be used to determine whether or not a pregnant woman is at risk of developing pre-eclampsia or whether or not a fetus is at risk of developing IUGR. Furthermore, antagonists of ADMA activity are useful in the inhibition or prevention of pre-eclampsia or inhibition or prevention of IUGR.

Description

technical field [0001] The present invention relates to the diagnosis of susceptibility to pre-eclampsia and intrauterine growth restriction (IUGR) and the prevention of their occurrence. Background technique [0002] Preeclampsia is a common condition in the UK, affecting 3-5% of human pregnancies and causing 40% of iatrogenic deliveries. It is a group of hypertensive disorders that also include eclampsia, latent chronic essential hypertension, kidney disease, and transient gestational hypertension. The disease is usually defined as acute hypertension with abnormal proteinuria in an otherwise normotensive woman after 20 weeks of gestation (Davey DA et al. Am J Obstet Gynecol 1988:158:892-8). Often it is also accompanied by pulmonary edema, cyanosis, hepatic impairment, visual or cerebral disturbances, pain in the epigastric region or upper right quadrant, low platelet count, intrauterine growth retardation (IUGR), or oliguria. Currently, the pathogenesis of preeclampsia i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68A01K67/027
CPCA01K2217/075G01N2333/471A01K2227/105G01N33/689A01K2267/03G01N2800/368A01K67/027A61P15/00A61P15/06A61P43/00
Inventor M·塞维多A·兴戈兰尼P·瓦兰斯K·尼科莱德斯
Owner UNIV COLLEGE OF LONDON
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