Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Chinese medicinal gel formulation, its preparation process and quality control method

A technology of gel preparation and traditional Chinese medicine, which is applied to the quality control of the gel preparation, the field of traditional Chinese medicine gel preparation and its preparation, and can solve the problems of prolonging the residence time of the drug in the cornea, poor drug absorption, and prolonging the action time. Achieve the effect of reducing gastrointestinal irritation, reducing other side effects, and not polluting clothes

Inactive Publication Date: 2006-07-12
北京凯瑞创新医药科技有限公司
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used dosage form in clinical practice is eye drops, but in clinical application, it is found that the eye drops have the disadvantages of short residence time in the eyes and poor drug absorption, so this study prepared the above drugs into ophthalmic gel Glue, this preparation can overcome the shortcomings of ordinary eye drops that tears can speed up the elimination of drugs, prolong the residence time of drugs in the cornea, so as to achieve the purpose of increasing drug absorption and prolonging the action time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Prescription: pearl liquid 20ml borneol 1.0g

[0042] Preparation method: Soak 2g of carbomer in 500ml of water for injection, let it stand overnight until the matrix is ​​fully moistened, add the pH regulator boric acid and borax, stir evenly, control the pH value to 5-7, and then add the antibacterial agent phenoxy Dissolve ethanol in 200ml of hot water at 80°C, let it cool, add pearl liquid, ethanol solution of borneol, and glycerin, mix well, then mix the above two liquids evenly, add water for injection to 1000ml, autoclave, stir well , first coarse filtration and then fine filtration to obtain a transparent gel, let it cool, and package it to make a finished product.

Embodiment 2

[0044] Prescription: pearl liquid 20ml borneol 1.0g

[0045] Preparation method: Soak 2g of hypromellose in 500ml of water for injection, let it stand overnight until the matrix is ​​completely moistened, then dissolve the antibacterial agent phenoxyethanol in 200m of hot water at 180°C, let it cool, add pearl liquid and borneol Ethanol solution, boric acid, borax, glycerin, mix evenly, then mix the above two liquids evenly, add water for injection to 1000ml, stir well, autoclave, first coarse filter and then fine filter to get a transparent gel, let it cool , packaged into a finished product;

Embodiment 3

[0047] Prescription: pearl liquid 20ml borneol 1.0g

[0048] Preparation method: first soak 3g chitosan in 500ml water for injection, add boric acid to dissolve it, then dissolve the antibacterial agent phenoxyethanol in 200ml hot water at 80°C, let it cool, add pearl liquid and borneol ethanol to dissolve liquid, boric acid, borax, glycerin, mix evenly, then mix the above two liquids evenly, add water for injection to the full amount, sterilize by autoclaving, stir well, first coarse filter and then fine filter to get a transparent gel, let cool, package finished product;

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a traditional Chinese medicinal gelling agent, wherein the main medicaments include pearl liquid or pearl powder hydrolysate and borneo camphor, the adjuvant includes right amount of gel base material, isotonic conditioning agent, pH modifier and water for injection. The invention also discloses the process for preparing the gel and the control method.

Description

technical field [0001] The invention relates to a traditional Chinese medicine gel preparation and a preparation method thereof, and also relates to a quality control method of the gel preparation, which belongs to the technical field of traditional Chinese medicine. Background technique [0002] Gel is a new form of traditional Chinese medicine. This study is a traditional Chinese medicine gel prepared by combining the commonly used traditional Chinese medicine pearl liquid or nacre powder hydrolyzate and borneol in ophthalmic diseases. It is used to prevent and treat ophthalmic diseases such as glaucoma. Juvenile pseudomyopia, early senile cataract, chronic conjunctivitis, etc. At present, the commonly used dosage form in clinical practice is eye drops, but in clinical application, it is found that eye drops have the disadvantages of short residence time in the eyes and poor drug absorption, so this study prepared the above drugs into ophthalmic gel Glue, this preparation...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K35/56A61K9/00A61P27/02G01N30/90G01N33/15A61K31/045A61K35/618
Inventor 代龙
Owner 北京凯瑞创新医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com