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Notoginseng glycol-saponin composition and its prepn and use

A technology of diol saponin and composition, which is applied in the field of purification and preparation of the traditional Chinese medicine Panax notoginseng, to achieve safe solvent, significant anti-inflammatory and analgesic effects, and significant anti-inflammatory and analgesic effects

Active Publication Date: 2006-05-17
成都中医大华神药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Panax notoginseng has a long history of being used to treat bruises, reduce swelling and relieve pain, there is no report about extracting medicines from Sanqi that can effectively treat rheumatism and rheumatoid arthritis.

Method used

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  • Notoginseng glycol-saponin composition and its prepn and use
  • Notoginseng glycol-saponin composition and its prepn and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Use a universal pulverizer (purchased from Shanghai Tianhe Pharmaceutical Machinery Factory, model GF-300) to pulverize 150 kg of dry rhizomes of Sanqi (place of origin: Wenshan, Yunnan Province), to a particle size range of 10 mesh to 24 mesh Sanqi coarse powder, use 2 The concentration of twice the weight of medicinal materials is 60wt% ethanol to soak the above-mentioned Panax notoginseng coarse powder and fill it into the percolation barrel, and the concentration of 10 times the weight of medicinal materials is 60wt% ethanol to percolate the wet material, collect the percolation liquid, and recover the percolation under reduced pressure After the ethanol in the solution, the alcoholic extract of Panax notoginseng saponins was obtained. The above-mentioned Panax notoginseng saponin alcoholic extract was prepared into an aqueous solution 10 times the weight of the medicinal material with purified water, and the resulting aqueous solution was loaded onto a styrene-type ...

Embodiment 2～5

[0046] According to the same method and steps as described in Example 1, ethanol with different concentrations and different weights was used to soak, percolate and elute the Panax notoginseng coarse powder to obtain the following composition of the present invention, and the results are shown in Table 2 below Show:

[0047]

Embodiment 6

[0049] Take 100g of the dried PDS dry cream obtained in Example 1, pulverize through a 100-mesh sieve, add 97.5g of starch and 2.5g of microcrystalline cellulose, mix well, dissolve in ethanol with a concentration of 50wt%, dry under reduced pressure, and pulverize , filled and made into capsules of 1000 or 2000 capsules.

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Abstract

The present invention belongs to the field of Chinese medicine, and is especially the purified product of notoginseng as one kind of Chinese medicinal materials and its preparation process and pharmaceutical use. The notoginseng glycol-saponin composition obtained through purifying notoginseng consists of ginsenoside Rb1 and ginsenoside Rd as main components, and contains ginsenoside Rb1 30-70 wt% and ginsenoside Rd 4-18 wt%, with the total content of ginsenoside Rb1 and ginsenoside Rd being up to 80 wt%. The notoginseng glycol-saponin composition has obvious antiflogistic and analgetic effect, low toxicity, and the features of nonsteroidal antiphlogistic. The composition may be used in preparing medicine for treating rheumatic and rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the purified product of the traditional Chinese medicine Panax notoginseng and its preparation method and pharmaceutical application. Background technique [0002] Panax notoginseng (Burk.) F.H.chen, also known as Tianqi, Panax notoginseng, Panax notoginseng, mountain lacquer, Jinbuhuan and blood ginseng, is a perennial herbaceous plant of the genus Panax Linn in the family Araliaceae , because it is excavated three to seven years after sowing and each plant has three petioles, and each petiole has seven leaves, so it is named Sanqi. Its stems, leaves, and flowers can be used as medicine. It is a unique and precious Chinese medicinal material in China. According to relevant documents, Panax notoginseng has been used for nearly 600 years and cultivated for nearly 500 years. Panax notoginseng is known as "gold does not change" and "sacred grass in the south...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K36/258A61P29/00
CPCA61K36/258A61P29/00
Inventor 万方康永华李明劲
Owner 成都中医大华神药业有限责任公司
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