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Apatite super-fine fiber material and its prepn. method

A technology of ultrafine fibers and fiber materials, applied in chemical instruments and methods, phosphorus compounds, artificial filaments of inorganic raw materials, etc., can solve the problems of nano-scale apatite ultrafine fibers with diameters that have not been seen, and achieve biodegradability Excellent, simple preparation process, large specific surface area

Inactive Publication Date: 2006-03-29
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are no research reports or invention patents on nano-scale apatite ultrafine fibers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Take 5g of triethyl phosphite, add 5g of distilled water, and hydrolyze for 100h under the condition of sealing and vigorous stirring. Then add 25 mL of 2 mol / L calcium nitrate aqueous solution, make it evenly mixed, and place it in a 45°C oven for 2 hours to obtain a sol solution. Get this sol solution 7mL and the ethanol mixing of 3mL, and add the M of 0.7g w Form the electrospinning solution for 1.3 million polyvinylpyrrolidone (PVP). It was placed in an electrospinning device, and electrospun under the conditions of a voltage of 15kV, a receiving distance of 12cm, a flow rate of 0.1ml / h, and a drum speed of 2m / min to obtain a white film. The electrospun membrane was air-dried at 85°C for 5 hours, and then calcined at 600°C for 10 minutes to obtain apatite fibers with a diameter of 300nm-500nm.

Embodiment 2

[0012] Take 1g of triethyl phosphite, add 1g of distilled water, and hydrolyze for 100h under the condition of sealing and vigorous stirring. Then add 5 mL of 2 mol / L calcium nitrate aqueous solution, make it evenly mixed, and place it in a 45°C oven for 2 hours to obtain a sol solution. Get this sol solution 4mL mixed with 1mL of ethanol, and add 0.35g of M w Form the electrospinning solution for 1 million polyvinylpyrrolidone (PVP). It was placed in an electrospinning device, and electrospun under the conditions of a voltage of 15kV, a receiving distance of 12cm, a flow rate of 0.1ml / h, and a drum speed of 2m / min to obtain a white film. The electrospun membrane was air-dried at 85° C. for 5 hours, and then calcined at 800° C. for 10 minutes to obtain apatite fibers with a diameter of 200 nm to 500 nm.

Embodiment 3

[0014] Take 5g of triethyl phosphite, add 5g of distilled water, and hydrolyze for 100h under the condition of sealing and vigorous stirring. Then add 25 mL of 2 mol / L calcium nitrate aqueous solution, make it evenly mixed, and place it in a 45°C oven for 2 hours to obtain a sol solution. Get this sol solution 9mL mixed with 1mL of ethanol, and add 0.6g of M w Form the electrospinning solution for 1.3 million polyvinylpyrrolidone (PVP). It was placed in an electrospinning device, and electrospun under the conditions of a voltage of 15kV, a receiving distance of 12cm, a flow rate of 0.1ml / h, and a drum speed of 2m / min to obtain a white film. The electrospun membrane was air-dried at 85° C. for 5 hours, and then calcined at 600° C. for 10 minutes to obtain apatite fibers with a diameter of 100 nm to 400 nm.

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Abstract

A superfine apatite fiber material used for repairing bone tissue is prepared through proportionally mixing triethyl phosphite with distilled water, hydrolyzing while stirring, adding the aqueous solution of calcium nitrate, stirring, ageing to obtain the gel solution, mixing it with alcohol, adding polyvinyl pyrrolidone to obtain the solution for electrospinning, electrospinning, drying and calcining. Its advantages are nano-class fineness, large specific surface area, high biodegradability and high affinity to cells.

Description

technical field [0001] The invention relates to an apatite superfine fiber material and a preparation method thereof, belonging to the technology of bone tissue repair materials. Background technique [0002] Hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 , HA] are relatively similar in structure and composition to the apatite crystals in human natural bone, and are the main bone repair material species (Yu Yaoting, Zhang Xingdong. Biomedical Materials [M], Tianjin: Tianjin University Press, 2002 12: 1-40, 145). The sol-gel method is an effective method for low-temperature synthesis of HA, and the generated HA has uniform composition, high purity and low crystallinity, and its structure is most similar to that of bone apatite (Liu DM, Troczynski T, TsengWJ, et al. Aging effect on the phase evolution of Water-based sol-gelhydroxyapatite, Biomaterials 2003, 23: 1227-1236). [0003] Ultrafine fibers with a diameter of nanometer to submicron can be prepared by electrospinning. The...

Claims

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Application Information

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IPC IPC(8): A61L27/12C01B25/37D01F9/08
Inventor 袁晓燕丁雅梅
Owner TIANJIN UNIV
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