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Menantine hydrochloride soft capsule and preparing method

A technology of memantine hydrochloride and soft capsules, which is applied in capsule delivery, active ingredients of amines, nervous system diseases, etc., and can solve problems such as unqualified content uniformity, unfavorable swallowing, and uneven mixing of main ingredients

Inactive Publication Date: 2006-03-08
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Memantine hydrochloride is flocculent, bitter in taste, and the dosage of the drug itself is small (10mg / time), when it is prepared into conventional tablets, problems such as uneven mixing of main ingredients and unqualified content uniformity are prone to occur, and it tastes bitter, Not conducive to swallowing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] prescription:

[0020] Memantine Hydrochloride 10g

[0021] PEG400 350g

[0022] Propylene glycol 40g

[0023] A total of 1000 capsules were made

[0024] Preparation:

[0025] First take the prescribed amount of propylene glycol, add memantine hydrochloride, dissolve it by ultrasonication, then add the prescribed amount of PEG400, stir evenly, and obtain a clear solution; adjust the weight of the contents, press the soft capsule, and dry it.

Embodiment 2

[0027] prescription:

[0028] Memantine Hydrochloride 10g

[0029] Absolute ethanol 25ml

[0030] PEG400 250g

[0031] Glycerin 15g

[0032] A total of 1000 capsules were made

[0033] Preparation:

[0034] First take the prescribed amount of absolute ethanol, add memantine hydrochloride, stir to dissolve, then add the prescribed amount of PEG400 and glycerin, and stir evenly to obtain a clear solution; adjust the weight of the contents, press soft capsules, and dry.

Embodiment 3

[0036] prescription:

[0037] Memantine Hydrochloride 10g

[0038] Absolute ethanol 20ml

[0039] PEG400824g

[0040] Propylene glycol 50g

[0041] Glycerin 100g

[0042] A total of 1000 capsules were made

[0043] Preparation:

[0044] First take the prescribed amount of absolute ethanol and propylene glycol, add memantine hydrochloride, stir to dissolve, then add the prescribed amount of PEG400 and glycerin, and stir evenly to obtain a clear solution; adjust the weight of the contents, press soft capsules, and dry.

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PUM

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Abstract

The present invention relates to a memantine hydrochloride soft capsule for curing senile dementia and its preparation method. It is made up by using memantine hydrochloride as raw material and adding a certain auxiliary material according to conventional process.

Description

technical field [0001] The invention relates to a novel pharmaceutical preparation, in particular to memantine hydrochloride soft capsules for treating senile dementia and a preparation method thereof. Background technique [0002] Senile dementia (Alzheimer's disease) is one of the common diseases of the elderly, mainly manifested as memory loss and cognitive impairment, etc., and is a progressive neurodegenerative disorder. A large number of research data at home and abroad show that one out of every ten elderly people shows different degrees of dementia symptoms, which seriously affects people's health and quality of life. The cost of research related to Alzheimer's in the United States is second only to AIDS. According to reports, the incidence rate of Alzheimer's disease in the United States accounts for about 10% among the elderly around the age of 65, and accounts for about 47% among the elderly over the age of 85. It has become the first disease after heart disease,...

Claims

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Application Information

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IPC IPC(8): A61K31/13A61K9/48A61P25/28
Inventor 严轶东
Owner FUKANGREN BIO PHARMA
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