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Vagina medicinal composition

A composition and drug technology, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of high drug cost, large drug dose, and large dose, and achieve improved drug convenience and drug use low dose effect

Inactive Publication Date: 2005-12-21
沈阳华泰药物研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the actual situation is that under the condition of the dose of 1g / suppository, there are two disadvantages: first, the dosage is large, which makes the cost of medication high; second, the dosage is too large, and the dosage form produced by industry is large, which is not conducive to administration medicine
[0016] The treatment method for 7 consecutive days, although the dosage is small and the therapeutic effect is good, but it is very inconvenient to the user because it needs to be used continuously for 7 days

Method used

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  • Vagina medicinal composition
  • Vagina medicinal composition
  • Vagina medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1, the preparation of tinidazole vaginal tablet

[0045] prescription:

[0046] Tinidazole 500g

[0047] Lactose 100g

[0048] Starch 50g

[0049] Microcrystalline Cellulose 50g

[0050] Calcium Lactate 30g

[0051] Lactic acid 24g

[0052] 2% HPMC aqueous solution

[0053] Magnesium Stearate 5g

[0054] Sodium Carboxymethyl Starch 50g

[0055] Make 1000 pieces

[0056] Preparation process: pulverize tinidazole, pass through a 100-mesh sieve, pulverize calcium lactate, pass through a 100-mesh sieve, pass lactose, starch, and microcrystalline cellulose through a 100-mesh sieve respectively, mix the above-mentioned raw and auxiliary materials according to the recipe quantity, and grind them evenly. , pass through a 60-mesh sieve, add lactic acid and an appropriate amount of 2% HPMC aqueous solution to make a soft material, granulate with a 16-mesh sieve, dry at 60°C for 3 hours, add the prescribed amount of magnesium stearate and sodium starch glycol...

Embodiment 2

[0057] Embodiment 2, the investigation of different prescriptions

[0058] Different prescriptions are examined to determine the most appropriate range of prescriptions. The inspection methods involved are generally described in the Chinese Pharmacopoeia and classic pharmacy textbooks.

[0059] Prescription I

[0060] Table 2 shows the results of the four formulations examined with hardness, fluidity, melting time, and friability as indicators.

[0061] project

[0062] From the index point of view, the formula II has the best fluidity and hardness after tableting.

Embodiment 3

[0063] Embodiment 3, the inspection of lactic acid in tinidazole vaginal tablet

[0064] Because lactic acid is contained in the prescription, the product is further explained by examining the amount of lactic acid added and the pH value of the product.

[0065] Tablets were made according to Example Recipe II by varying the amount of lactic acid. Then grind the tablet finely, get about 2.5g of the product fine powder, add 50ml of water, dissolve, filter, take the filtrate, measure the pH value according to the Chinese Pharmacopoeia 2000 edition two appendix VI (H) method, the results are shown in Table 3.

[0066] Amount of lactic acid (mg / tablet)

[0067] This test found that when the amount of lactic acid was 4-2.0 mg / tablet, there was a better pH range.

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Abstract

The present invention relates to a medicine composition for vagina, in particular, it relates to a medicine composition containing tinidazole and lactic acid. Said invention also relates to the preparation method of said medicine composition and pH value determination method of said medicine composition. Besides, said invention also provides the application method of said medicine composition.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for vaginal use, in particular, the present invention particularly relates to a pharmaceutical composition containing tinidazole and lactic acid, the present invention also relates to a preparation method of the pharmaceutical composition, and a method for measuring the pH value of the composition . Background technique [0002] Vaginal infection, including fungal vaginitis, trichomonas vaginitis, bacterial vaginitis and mixed vaginitis, is an important disease that threatens women's reproductive health ( Fu Xueyan, etc., Harbin Medicine, 2004, 24(4): 16-17 ). Because patients can develop other diseases and affect the quality of life, it is necessary to develop corresponding therapeutic drugs. [0003] Tinidazole is described in detail in the 13th edition of the Merck Index, and its English name is Tinidazole. Typical tinidazole instructions for use describe it as follows: for various an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4164
Inventor 王鹏
Owner 沈阳华泰药物研究有限公司
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