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Total saponin extract of dioscorea nipponica stem and leaf and its extraction process and medicine use

A technology of Dioscorea sinensis and total saponins, which is applied in the field of total saponin extract of Dioscorea sinensis stems and leaves and its extraction and its medicinal use, can solve problems such as unseen utilization, and achieve the effect of expanding drug sources.

Inactive Publication Date: 2005-12-14
李平亚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are no reports on the research and utilization of Dioscorea chinensis, because Dioscorea chinensis can only be harvested and utilized every 4 years, while its aboveground part has dense stems and leaves, and the stem height can reach 2-3 meters. It can be used every year, and the resources are very rich. , while no use has been made so far

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] a. Crush the aboveground part of Dioscorea punctatus, boil and extract 3 times with 20 times the amount of water, each time for 3 hours, 2 hours, and 1 hour respectively, filter, and combine the extracts;

[0041] b. Apply the extract obtained in step a to a macroporous adsorption resin D4020 column, wash with water until colorless, then elute with 80% ethanol, collect the eluate, recover the ethanol to extract, and dry.

Embodiment 2

[0043] a. Crush the aboveground part of Dioscorea punctatus, boil and extract 3 times with 22 times the amount of water, each time for 3h, 2h, and 1h, filter, and combine the extracts;

[0044] b. Apply the extract obtained in step a to a macroporous adsorption resin D101 column, wash with water until colorless, then elute with 85% ethanol, collect the eluate, recover the ethanol to extract, and dry.

Embodiment 3

[0046] a. Crush the above-ground part of Dioscorea punctatus, boil and extract 3 times with 25 times the amount of water, each time for 3 hours, 2 hours, and 1 hour respectively, filter, and combine the extracts;

[0047] b. Apply the extract obtained in step a to a macroporous adsorption resin column, wash with water until colorless, then elute with 95% ethanol, collect the eluate, recycle the ethanol to extract, and dry.

[0048] The embodiment one of preparation medicament:

[0049] Take 50g of the total saponins extract from the stems and leaves of Dioscorea punctatus, add 250g of medicinal starch, and mix the two thoroughly to make 1000 capsules, each weighing 0.3g, containing 50mg of the total saponins extract from the stems and leaves of Dioscorea punctatus.

[0050] The embodiment two of preparation medicament:

[0051] Take 65g of the total saponins extract from the stems and leaves of Dioscorea punctatus, add 235g of medicinal starch, mix the two thoroughly, and mak...

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Abstract

The present invention discloses total saponin extract of dioscorea nipponica stem and leaf and its extracting and refining process and medicine use, and belongs to the field of new Chinese medicine extract. The above-ground parts of Chinese medicine material dioscorea nipponica is processed through water decoction, elution in macroporous adsorption resin with water to no color, elution with 80-95 % concentration ethanol solution to collect eluate, and recovering ethanol to obtain one new kind of Chinese medicine material. The total saponin extract of dioscorea nipponica stem and leaf has the effect of treating coronary heart disease, angina pectoris, myocardial ischemia, hyperlipemia and other diseases.

Description

technical field [0001] The invention relates to an extract from a new medicinal part of a traditional Chinese medicine, an extraction method and a medicinal application thereof. Background technique [0002] Dioscorea nipponica Makino is a plant of Dioscorea family, and its root is used as medicine, commonly known as Dioscorea nipponica Makino. Produced in Inner Mongolia, Heilongjiang, Sichuan, Anhui, Jiangsu and other provinces. Its main effective part is total diosgenin, which is not only the main drug source for the production of drugs for treating cardiovascular diseases, but also one of the important drug sources for diosgenin (diosgenin) used in the synthesis of various steroid hormones and contraceptive drugs. Clinical studies have proved that the total saponins of Dioscorea chinensis have certain curative effects on lowering blood fat, relieving asthma, anti-inflammation and anti-tumor. There are many kinds of such saponins, but they all have the same basic skeleto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J71/00
Inventor 李平亚卢丹
Owner 李平亚
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