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Biological degradable polyester micropartical and its preparation process and application

A technology for degrading polyester and microparticles, which is applied in the field of biodegradable polyester microparticles or microspheres and its preparation, which can solve the problems of high material cost and cumbersome polymerization process, and achieve uniform particle size, simple process and good application prospects Effect

Active Publication Date: 2005-11-09
长春宸泰科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the raw materials of this particle need to polymerize L-lactide and D-lactide separately, the polymerization process is relatively cumbersome
At the same time, because the price of D-lactide is much higher than that of L-lactide and D-lactide, the cost of materials is relatively high

Method used

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  • Biological degradable polyester micropartical and its preparation process and application
  • Biological degradable polyester micropartical and its preparation process and application
  • Biological degradable polyester micropartical and its preparation process and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Using stereoactive multi-block polylactide (n=8.2) with different molecular weights and high stereoregularity as materials, microparticles or microspheres were prepared by adopting the cooling method included in the method of the present invention.

[0034] Divided into four steps:

[0035] 1) Weigh 50 mg of stereo-optical multi-block polylactide (n=8.2) with number-average molecular weights of 2800, 8700, 13600, 23200, and 79800 Da, respectively, and dissolve them in dichloromethane solvent, and the solution reaches 50 mL;

[0036] 2) Move the polymer solution to a 250mL round bottom flask, and slowly add absolute ethanol dropwise to each of them until the solution starts to become slightly cloudy;

[0037] 3) Store the mixed solvent system of the above polymers at -20°C for 24 hours to precipitate the polymers;

[0038] 4) The suspension was centrifuged at -20°C for 10 min, the supernatant was discarded, and the precipitate was vacuum-dried at room tempera...

Embodiment 2

[0041] Example 2: Using stereoactive multi-block polylactide (n=8.2) with different molecular weights and high stereoregularity as materials, microparticles or microspheres were prepared by the solvent evaporation method included in the method of the present invention.

[0042] Be divided into four steps, wherein step 1) and 2) are the same as embodiment 1, also have the following steps:

[0043] 3) respectively place the mixed solvent system of the above-mentioned polymers at room temperature and stir for 12 hours to completely volatilize the dichloromethane and precipitate the polymers;

[0044] 4) The resulting suspension was centrifuged at room temperature for 10 min, the supernatant was discarded, and the precipitate was vacuum-dried at room temperature for 24 h.

[0045] The obtained microparticles were cake-shaped, and the particle diameters are shown in Table 2.

[0046] Number average molecular weight (M n )

Embodiment 3

[0047] Example 3: Using stereoactive multi-block polylactide (n=8.2) with different molecular weights and high stereoregularity as materials, microparticles or microspheres were prepared by using the non-solvent precipitation method included in the method of the present invention.

[0048] Be divided into four steps, wherein step 1) and 2) are the same as embodiment 1, also have the following steps:

[0049] 3) Slowly add a large amount of absolute ethanol (50-5000 mL) to the mixed solvent system of the above polymer to precipitate the polymer;

[0050] 4) The resulting suspension was centrifuged at room temperature for 10 min, the supernatant was discarded, and the precipitate was vacuum-dried at room temperature for 24 h.

[0051] The obtained microparticles were cake-shaped, and the particle diameters are shown in Table 3.

[0052] Number average molecular weight (M n )

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Abstract

A biodegradable polyester microparticle or microsphere for controlling the release of medicine is prepared from levo-and dextro-cubic polyblock polylactide through cooling method, solvent voltilizing method, or non-solvent depositing method.

Description

technical field [0001] The invention belongs to the technical field of polyester particle preparation, and in particular relates to biodegradable polyester particles or microspheres, a preparation method and application thereof. Background technique [0002] In the past ten years, polymer particles, including microcapsules and microspheres, have received extensive attention in the field of controlled drug release. Using it as a carrier of small-molecule drugs can achieve the effects of improving drug utilization and reducing toxic and side effects. Being used as a carrier of protein and polypeptide drugs can overcome the short half-life of protein and polypeptide drugs and the shortcomings of being easily hydrolyzed in vivo. The different sizes of the microparticles can also make the drug release targeted. At the same time, through the slow release of drugs, drug-loaded polymer particles can reduce the number of administrations and improve patient compliance. [0003] The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/08
Inventor 陈学思胡俊丽汤朝晖邱雪宇杨永坤庄秀丽景遐斌
Owner 长春宸泰科技有限公司
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