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Process for preparing medicinal syrup

A syrup and drug technology, applied in the field of drug syrup preparation, can solve the problems of darkening color, long time required, and susceptibility to microbial contamination, so as to achieve the effects of reducing production, reducing production costs, and inhibiting microbial growth

Inactive Publication Date: 2005-10-19
丰丽妍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is suitable for the preparation of heat-stable drugs and colored syrups. It has the advantages of easy filtration and killing microorganisms. However, when the heating is too long or exceeds 100 ° C, the content of invert sugar will increase, and the color of the product will become darker. Suitable for the preparation of drug syrups with low solubility
[0004] The cold dissolving method is to dissolve sucrose in cold water or a drug-containing aqueous solution, which can be completed in a closed container or a osmosis cartridge. This method is more suitable for drugs that are unstable and volatile when exposed to heat, but it takes a long time and is easy to process during the production process. microbial contamination

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 adopts the following parts by weight ratio components:

[0035] 580, 630 or 680 parts of purified water, 10, 20 or 30 parts of medicine, 2, 7 or 10 parts of auxiliary materials, 600, 630 or 650 parts of sucrose, 5, 10 or 15 parts of glycerin, and the medicine can be ferrous lactate , fluorouracil, or acetaminophen,

[0036] Take purified water, heat to 100°C, cool to 65, 70 or 85°C, add drugs and excipients in order, stir while adding, to completely dissolve drugs and excipients; then add 600, 630 or 650 parts of sucrose, and add While stirring, heat to 80, 90 or 100°C, filter while hot after the sucrose is completely dissolved, put it at room temperature, add 5, 10 or 15 parts of glycerin, and divide into packages to make it.

Embodiment 2

[0037] Example 2 Preparation of fluorouracil syrup: adopt the following parts by weight ratio:

[0038] The drug is 10, 20 or 30 parts of fluorouracil, 600, 625 or 650 parts of sucrose, 1, 1.5 or 2 parts of citric acid (containing 1 molecule of crystal water) and 1.5 parts of potassium sorbate, 5, 10 or 15 parts of glycerin parts, 580, 620 or 680 parts of purified water,

[0039] Take purified water, heat it to 100°C, cool it to 65, 70 or 85°C, add fluorouracil, citric acid and potassium sorbate in sequence, stir while adding, so that the drug and excipients are completely dissolved; add sucrose, stir while adding , heated to 90, 95 or 100°C to dissolve the sucrose completely, filter while it is hot, place it at room temperature, add glycerin, and pack it separately.

Embodiment 3

[0040] Example 3 Preparation of acetaminophen syrup: using the following parts by weight ratio:

[0041] The drug is 10, 20 or 30 parts of paracetamol, 600, 625 or 650 parts of sucrose, 1, 2 or 4 parts of vitamin C and 4 parts of sodium benzoate, 580, 630 or 680 parts of purified water,

[0042] Take purified water, heat it to 100°C, cool it to 65, 70 or 85°C, add vitamin C, paracetamol and sodium benzoate in turn, and stir while adding, so that the drug and auxiliary materials are completely dissolved; add sucrose, add while adding Stir, heat to 80, 85 or 90°C to completely dissolve the sucrose, filter while it is hot, place it at room temperature, and pack it.

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PUM

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Abstract

The medicine syrup preparing process includes heating pure water to 100 deg.c, cooling to 65-85 deg.c, adding medicine and supplementary material while stirring for dissolving medicine and supplementary material completely, adding sucrose and heating to 80-100 deg.c while stirring for dissolving, and filtering while the syrup is hot. The present invention is suitable for compounding syrup with inferior solubility medicine, and has low temperature, less medicine oxidation, degradation and volatilization, less generation of reducing sugar, low cost and other advantages.

Description

technical field [0001] The invention relates to a preparation method of a medicine syrup. technical background [0002] Syrups are aqueous solutions of drugs or fragrances containing high concentrations of sucrose. Currently, they are mostly prepared by dissolution methods. The dissolution methods include hot-dissolution and cold-dissolution methods: [0003] The hot-melt method is to dissolve sucrose in a certain amount of boiling water, continue to heat, add other medicines at an appropriate temperature, stir to dissolve, then add water to the full amount through a filter, and pack separately. This method is suitable for the preparation of heat-stable drugs and colored syrups. It has the advantages of easy filtration and killing microorganisms. However, when the heating is too long or exceeds 100 ° C, the content of invert sugar will increase, and the color of the product will become darker. It is suitable for the preparation of drug syrups with low solubility. [0004] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/167A61K31/191A61K31/4375A61K31/513
Inventor 丰丽妍
Owner 丰丽妍
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