Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Vaginal gel tablets

A technology of gel sheet and vagina, applied in the field of gynecological vagina gel sheet, can solve the problems of prolonging the medication interval, inconvenient use, and difficulty in expelling the medicine from the body.

Inactive Publication Date: 2005-10-12
凌沛学
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Hydrophilic gel material is used as the matrix of vaginal gel. Because of its high viscosity and bioadhesion, the drug can be distributed in the mucosal space and folds to maintain long-term close contact with the mucosa; It is not easy to be excreted from the body, the drug has a long action time, high bioavailability of the drug and the advantages of prolonging the interval between medications; but because the gel has the advantages of large volume, production, carrying, transportation, storage, inconvenient use, high cost and water-based liquid preparations are easy to cause mildew Changes, easy to cause chemical degradation of drugs, lower drug efficacy or even failure, and poor stability, which limits its wide application
Vaginal effervescent tablets have the advantages of fast onset of action, easy mass production, convenient use, carrying, transportation, and storage, low cost, and good drug stability during storage; relatively short duration of action

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Shuangzotai Gel Tablets

[0018] Prescription (based on 1000 tablets)

[0019] Metronidazole 200g

[0020] Clotrimazole 160g

[0021] Chlorhexidine acetate 8g

[0022] Hydroxypropyl Methyl Cellulose 100g

[0023] Sodium bicarbonate 150g

[0024] Citric acid 100g

[0025] Starch 50g

[0026] 10% starch paste appropriate amount

[0027] Magnesium Stearate 3.5g

[0028] Preparation method: pass metronidazole, clotrimazole, chlorhexidine acetate, hydroxypropyl methylcellulose, sodium bicarbonate, and starch through an 80-mesh sieve, mix well, and granulate with 10% starch paste; citric acid passes through 80 mesh Mesh sieve, granulate with 10% starch paste; the above two granules are respectively dried at 60°C, granulated, mixed evenly, added with magnesium stearate, mixed evenly, compressed into tablets, and packed in double aluminum.

Embodiment 2

[0030] Nystatin Gel Tablets

[0031] Prescription (based on 1000 tablets)

[0032] Nystatin 50 million units

[0033] Carbomer 934 100g

[0034] Boric acid 120g

[0035] Sodium bicarbonate 100g

[0036] Microcrystalline Cellulose 130g

[0037] Pregelatinized starch 50g

[0038] Micronized silica gel 50g

[0039] Preparation method: Take nystatin plus pregelatinized starch, grind it a little, mix it with the remaining pregelatinized starch, and set aside; borax and sodium bicarbonate are respectively passed through 80 mesh sieves; microcrystalline cellulose and carbomer 934 are dried at 80°C and passed through 80 mesh sieve. Mix the above powder evenly, add micropowder silica gel, pass through a 40-mesh sieve, directly compress into tablets, and pack in double aluminum.

Embodiment 3

[0041] Nonoxynol Gel Tablets

[0042]Prescription (based on 1000 tablets)

[0043] Nonoxynol 75g

[0044] Xanthan gum 40g

[0045] Sodium bicarbonate 80g

[0046] Potassium Bitartrate 200g

[0047] Sodium Carboxymethyl Cellulose 100g

[0048] 10% starch paste appropriate amount

[0049] Magnesium Stearate 2.5g

[0050] Preparation method: pass nonoxynol ether, xanthan gum, and sodium carboxymethyl starch through a 80-mesh sieve, granulate with 10% starch paste, dry at 60°C and set aside; pass through a 80-mesh sieve for sodium bicarbonate and potassium hydrogen tartrate, respectively 10% starch paste was granulated, dried at 40°C and set aside. Mix the three kinds of granules, add magnesium stearate, mix evenly, press into tablets, and pack in double aluminum.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A vaginal gel tablet for treating gynopathy contains hydrophilic gel material (1-40%) and effevescent disintegrant or superdisintegrant (20-50%). It advantages are quickly taking its effect and durable action.

Description

technical field [0001] The invention relates to a gynecological vaginal gel sheet, which belongs to the technical field of medicines. Background technique [0002] Vaginal mucosal administration has a history of nearly a hundred years. Compared with traditional oral administration, it has many advantages. It is a very effective drug sustained release system; it can be used not only locally, but also systemically. The drug is administered locally through the vaginal mucosa, which can increase the local drug concentration, give full play to the curative effect of the drug, and avoid systemic effects; the drug can exert a systemic effect through the absorption of the vaginal mucosa, which can avoid the hepatic first-pass effect of the drug, improve bioavailability, and reduce side effects , Also avoid the gastrointestinal reactions of certain drugs. [0003] Common dosage forms for vaginal mucosal administration include suppositories, effervescent tablets and gels. Suppositor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/20A61P15/02
Inventor 凌沛学张建强张玲
Owner 凌沛学
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com