Apparatus for forming molecular timetable and appratus for estimating circadian clock

Abstract

An apparatus (11) for estimating internal biological time of a biological individual on the basis of quantity data of a gene product as measured in a specimen sampled from the individual. The apparatus includes circadian oscillatory gene selection means for selecting circadian oscillatory genes whose time-course change in gene product quantity data as measured in standard specimens approximates a cosine curve having a predetermined period; circadian expression curve selection means for selecting, from among a plurality of cosine curves having different phases and sharing a specific period, a circadian expression curve which is similar to the pattern of time-course change in the expression product quantity of each of the above-selected circadian oscillatory genes; and registration means for registering information which identifies the selected circadian expression curve.

Description

technical field [0001] The present invention relates to a molecular timetable generation device, an in vivo time estimation device, a molecular timetable generation method, an in vivo time estimation method, a molecular timetable generation program, an in vivo time estimation program and an in vivo time estimation system, in particular to Molecular timetable generating device capable of easily estimating in vivo time using a computer, in vivo time estimating device, molecular time table generating method, in vivo time estimating method, molecular timetable generating program, in vivo time estimating program, and in vivo time estimating system . Background technique [0002] Many organisms have internal biological clocks that control various biological rhythms such as sleep-wake rhythm, blood pressure rhythm, body temperature rhythm, and some hormone secretion rhythms. [0003] The oscillation period of the biological clock in the body is about 24 hours, but there are some d...

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Problems solved by technology

[0008] However, the problem is that these methods require blood collection or temperature measurement over 24 hours over time, which places a heavy burden on patients and medical workers, and cannot be said to be realistic methods for use in the medical field.

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