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Method for preparing agent of cyclodextrin-cellulose for adsorbing uric acid

A technology of cyclodextrin and cellulose, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, urinary system diseases, etc., can solve the problems that there are no research reports on uric acid oral adsorbents, etc., achieve no toxic side effects, and simple preparation process , the effect of convenient source

Inactive Publication Date: 2005-08-31
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there is no domestic research report on uric acid oral adsorbents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0014] Add 4g of α-cellulose into 24mL of 20% NaOH solution, slowly add 6mL of epichlorohydrin dropwise, react at 30°C for 2h, filter and dry, then add 0.85g of the product into 100mL of 30% NaOH solution, and then add 0.2g of β-cyclo Dextrin was reacted at 30°C for 2 hours to obtain a cyclodextrin-cellulose adsorbent.

example 2

[0016] Add 4g of α-cellulose into 24mL of 25% NaOH solution, slowly add 24mL of 1,2-ethylene glycol diglycidyl ether dropwise, react at 40°C for 3h, filter and dry, then add 1.7g of the product into 100mL of 30% NaOH solution, Add 0.7 g of methyl β-cyclodextrin and react at 40° C. for 2 hours to obtain a cyclodextrin-cellulose adsorbent.

example 3

[0018] Add 4g of microcrystalline cellulose into 24mL of 30% NaOH solution, slowly add 36mL of epichlorohydrin dropwise, react at 50°C for 5h, filter and dry, then add 3.4g of the product into 100mL of 30% NaOH solution, and then add 1.4g of hydroxyl Propyl β-cyclodextrin was reacted at 50°C for 3 hours to obtain a cyclodextrin-cellulose adsorbent.

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Abstract

A uric acid absorbent is prepared through dissolving cellulose in NaOH solution, adding cross-linking agent, polymerizing reaction, proportionally adding cyclodextrin, reaction, drying, and pulverizing. It has high adsorptive speed and power to uric acid.

Description

technical field [0001] The invention relates to a preparation method of a cyclodextrin-cellulose uric acid adsorbent, which belongs to the uric acid adsorbent technology. Background technique [0002] Uric acid is an important metabolite in the human body, especially in diseases such as chronic renal failure, hyperuricemia and hyperlipidemia. Clinically, hemodialysis is generally used, and oral sorbent is a new, convenient and effective treatment method. Excreted together with the feces, so as to achieve the purpose of relieving the symptoms and inhibiting the further deterioration of the condition. [0003] So far, there is no research report on uric acid oral adsorbent in China. Contents of the invention [0004] The purpose of the present invention is to provide a preparation method of a cyclodextrin-cellulose uric acid adsorbent, the preparation process of which is simple, the prepared adsorbent has a strong abi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/724A61P13/12
Inventor 孟舒献冯亚青张卫红
Owner TIANJIN UNIV
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