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Suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process

The technology of lipiodol and suspension is applied in the field of medicines and preparations of magnetic microspheres for treating tumors, and can solve the problems of difficulty in selectively entering the embolization target area, insufficient and durable embolization effect, etc.

Inactive Publication Date: 2005-07-06
KUNMING MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

with Fe 3 o 4 As a permanent peripheral embolic agent, microparticles have been proved to have a good embolism effect through basic experiments and clinical research, and Fe 3 o 4 While blocking the blood flow, the magnetic field of the microparticles can still inhibit the tumor cells to a certain extent; however, it is difficult to selectively enter the embolization target area.
As a pro-tumor carrier, lipiodol can carry anticancer drugs selectively into tumor tissue, and has good orientation and certain embolization effect. The effect is not thorough and long-lasting

Method used

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  • Suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process
  • Suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process
  • Suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process

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Embodiment Construction

[0100] Embodiments consistent with the subject matter of the technical solution of the present invention have the following methods:

[0101] 1. Embolization of rabbit renal artery.

[0102] Fe3O4 particles with a particle size of 250 μm were mixed with iodized oil at a ratio of 100 mg: 1 ml, injected in vitro with a 3-6F catheter, and the passage of the suspension was observed; 15 New Zealand white rabbits with certificates were used for group control experiments , using rabbit femoral artery puncture, intubation to the right rabbit renal artery, the experimental group (10) embolized with STML with a particle size of 250 μm, and the control group (5) embolized with lipiodol. Animals in the experimental group underwent angiography on 3 days, 1 week, 2 weeks, 4 weeks, 6 weeks, and 8 weeks after operation; animals in the control group underwent angiography on 3 days, 1 week, 2 weeks, 4 weeks, and 6 weeks after operation. Efficacy; X-ray plain films were used to observe the dens...

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Abstract

The invention relates to a suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process, wherein the suspension wherein the suspension is prepared by fully mixing 50um-300um Fe3O4 particles with non-limited specification and iodized oil by the proportion of 85-110mg : 1ml.

Description

Technical field [0001] The invention belongs to a medicine for treating tumor with magnetic microspheres and a preparation method thereof, in particular to a magnetic microsphere suspension and a preparation method for treating liver and kidney tumors through arterial-guided embolization. Background technique [0002] The onset of liver cancer is insidious, and most patients are diagnosed in the middle or late stage. In addition, many factors such as liver disease background and high surgical recurrence rate lead to a low surgical resection rate of liver cancer. Therefore, most patients with liver cancer adopt non-surgical treatment. Currently, hepatic artery embolization has become the main method for the treatment of advanced liver cancer among the non-surgical treatments with positive curative effect. However, common embolic agents also cause embolization of some normal blood vessels while embolizing tumor blood vessels, which is undoubtedl...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K33/26A61K45/08A61K47/02A61P35/00
Inventor 袁曙光阎东顾亚律郭立王家平程新宝李迎春普成荣韩正林
Owner KUNMING MEDICAL UNIVERSITY
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