Enteric coated type thin membrane coated premixed agent and preparation method thereof

Abstract

Disclosed is an enteric coated type thin membrane coated premixed agent and preparation method, which comprises intestine dissoluble cellulose derivative, intestine dissoluble acrylic resin derivative, polyethylene glycol 6000. The intestine soluble type thin film coated premix has advantages of low cost, simple process for manufacturing, thus fitting for mass production.

Description

technical field [0001] The invention relates to a film coating premix and a preparation method of the film coating premix. Background technique [0002] Film coating is to uniformly spray a layer of relatively stable polymer coating on the surface of solid pharmaceutical preparations by spraying to form a plastic film layer with a thickness of several microns. [0003] Enteric-coated film coating is suitable for the coating of drugs that do not dissolve in gastric juice but need to be dissolved in intestinal juice. The material must be insoluble or seldom dissolved when it encounters digestive juice such as gastric acid, so as to effectively avoid oral cavity, esophagus, stomach and other parts. Drug release, but does not affect the dissolution and dissolution time of the drug in intestinal juice. Commonly used materials for enteric film coating include enteric acrylic resin derivatives, enteric cellulose derivatives and enteric polyethylene derivatives. [0004] Most of t...

AI Technical Summary

Problems solved by technology

[0004] Most of the existing various enteric-coating film coating premixes, due to the unreasonable selection of polymers or unreasonable composition ratios, some of them have too low viscosity after being formulated into coating slurry, resulting in the coating of solid pharmaceutical preparations The adhesion between the coating film of the finished product and the core of the drug is poor, and the surface of the finished product is worn, and the edge of the film is cracked or peeled off; some have too high viscosity, and it is easy to form larger droplets during the coating process, which is difficult to distribute evenly On the surface of the drug, there is a lot of aggregation on the surface of the drug to cause adhesion, and the density of the coating film is also poor, resulting in many bubbles; when the viscosity of the coating slurry is too high, it can also cause the surface of the coating layer of the final film coating product Rough and wrinkled skin, etc.; when there are nicks or marked drug cores on the coating surface, if the composition of the coating premix is ​​unreasonable, the mechanical parameters of the coating film will be unreasonable, such as the elastic coefficient is too high and the film strength is poor , Adhesion is not good, etc. During the drying process of the coating film, a high pullback force is generated, the surface of the coating film is pulled up from the score, and the film retracts, resulting in bridging phenomenon, so that the score on the surface of the drug disappears or The logo is not clear