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Chinese medicine composition for treating dizziness and its preparing and quality control method

A traditional Chinese medicine preparation and decoction technology, which is applied in the direction of drug combination, testing of drug preparations, and medical formulas, can solve the problems of affecting drug efficacy, incomplete extraction with ordinary water, and backward preparation technology, so as to reduce losses and ensure uniformity and effectiveness, the effect of improving the efficacy of drugs

Active Publication Date: 2005-05-18
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, in the field of traditional Chinese medicine, Vertigo Ning Decoction is mostly used to treat Meniere's disease to obtain satisfactory results. Its preparation technology is backward, and it is used as medicine in decoction. drug effect

Method used

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  • Chinese medicine composition for treating dizziness and its preparing and quality control method
  • Chinese medicine composition for treating dizziness and its preparing and quality control method
  • Chinese medicine composition for treating dizziness and its preparing and quality control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 Preparation of granules of the present invention

[0042] Weigh 150g of Gastrodia elata, 300g of Uncaria, 600g of Alisma, 300g of Pinellia, 360g of Atractylodes macrocephala, 360g of Poria, 300g of Radix Paeoniae Alba, 300g of Zhuru, 90g of Chuanxiong, 90g of licorice, 180g of tangerine peel, and 135g of ginger

[0043] The above twelve flavors, tangerine peel, ginger and 2835g of water are extracted to obtain volatile oil, and the dregs are used for later use; the volatile oil is encapsulated with 5g of β-cyclodextrin at 50°C for later use; the remaining medicinal solution is concentrated to a relative density of 1.18 (50°C), and ethanol is added Make the alcohol content 50%; decoct the dregs of the medicinal herbs, white peony root, poria cocos, licorice, and Zhuru twice with water, add 13650g of water for the first time, decoct for 1.5 hours, add 10920g of water for the second time, decoct for 1 hour, and decoct together Liquid, filtered, concentrated un...

Embodiment 2

[0045] The selection of embodiment two tangerine peel, ginger volatile oil extraction conditions

[0046] In order to select the best extraction process conditions of tangerine peel and ginger volatile oil, 600 grams of tangerine peel and 450 grams of ginger medicinal materials were taken, a total of 9 parts, the amount of water added, the extraction time and the amount of salt added were carried out in an orthogonal test, as shown in Table 1. Taking the yield of volatile oil (v / w, v is the volume of volatile oil, and w is the quality of medicinal materials) as the investigation index, 9 experiments were carried out, and the levels of each factor are shown in Table 1.

[0047] Table 1 Orthogonal result table of extracting volatile oil from tangerine peel and ginger

[0048]

[0049] R 0.66 0.15 0.06

[0050] Table 2 Orthogonal test analysis of variance table for extracting volatile oil from tangerine peel and ginger

[0051] Source of Variance Sum of Squares ...

Embodiment 3

[0058] Example 3 Selection of volatile oil inclusion conditions

[0059] Since the medicine contains volatile oil extracted from tangerine peel and ginger, in order to minimize the loss of volatile oil, β-cyclodextrin inclusion technology is used to make it inclusion. Orthogonal experiments were designed to select the best conditions for inclusion junctions. Choose L9(3 4 ) orthogonal table, taking the inclusion rate of volatile oil as the investigation index, 9 experiments were carried out, and the levels of each factor are shown in Table 3.

[0060] Table 3 Orthogonal results of β-cyclodextrin inclusion in volatile oil

[0061]

[0062] K3 193.60 165.50 194.10

[0063] R 14.10 59.00 8.90

[0064] Inclusion rate = [amount of volatile oil in inclusions (g) / amount of volatile oil added (g)] × 100%

[0065] Table 4 Analysis of variance table of orthogonal test of β-cyclodextrin inclusion in volatile oil

[0066] Source of Variance Sum of Squares Degrees o...

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Abstract

The Chinese medicine composition is used in treating dizziness, nausea and vomiting, especially Meeniere's syndrome, and has the functions of eliminating phlegm, preventing dizziness, regulating the middle warmer and stopping vomiting. It is prepared with 12 kinds of Chinese medicinal materials, including gastrodia tuber, hooked uncaria, oriental water plantain, pinellia tuber, etc. and contains also beta-cyclodextrin as volatile oil including agent, beta-cyclodextrin as co-solvent for liposoluble component, aspartame as corrective and dextrin as excipient. The quality control method during the preparation process includes thin layer identification of hooked uncaria, white peony root, Chuanxiong rhizome and licorice, and measurement of gastrodin in gastrodia tuber as main material and paeoniflorin in white peony root.

Description

technical field [0001] The present invention relates to a kind of medicine that has the effect of eliminating phlegm and calming dizziness, harmonizing stomach and antiemetic, treating dizziness, nausea and vomiting, especially suitable for Meniere's disease (now called Meniere's disease) and its preparation and quality control method. It belongs to the field of traditional Chinese medicine. Background technique [0002] Vertigo is a common symptom among middle-aged and elderly people. It is often sudden and often occurs after waking up or turning the head and neck to one side. The main clinical symptoms are dizziness, tinnitus, nausea and vomiting, visual rotation, sweating all over the body, and allergies to strong light and noise. Hypertensive arteriosclerosis is a common cause of vertigo in the elderly. The small arteries spasm due to elevated blood pressure, coupled with the narrowing of the arterial lumen, the vertebrobasilar artery will cause insufficient blood suppl...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61P9/02G01N30/02G01N33/15
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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