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Chitose microsphere and microcapsule with uniform size and its preparation method

A technology of chitosan microspheres and chitosan, which is applied in the field of pharmaceutical preparations in medical engineering, can solve the problems of poor dispersion, uneven particle size of chitosan drug carriers, and low embedding rate, and achieve uniform particle size, Maintain high activity and good reproducibility

Active Publication Date: 2005-04-20
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] This technology solves the problems of uneven particle size, low embedding rate and poor dispersion of chitosan drug carriers prepared by traditional stirring emulsification method

Method used

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  • Chitose microsphere and microcapsule with uniform size and its preparation method
  • Chitose microsphere and microcapsule with uniform size and its preparation method
  • Chitose microsphere and microcapsule with uniform size and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The hydrophobic membrane with a pore size of 4.7 μm is immersed in a lipophilic substance to fully wet the porous membrane to ensure that the hydrophobic chains on the membrane are completely stretched. Prepare 1wt% acetic acid aqueous solution, add a certain amount of NaCl and dissolve it under stirring, its concentration is 1wt%, then add a certain amount of chitosan to make its concentration 2wt%, after it is completely dissolved, filter the solution spare. Add the oil-soluble emulsifier to 60 ml of the mixed oil phase of liquid paraffin and petroleum ether, and stir until completely dissolved to form the oil phase. The water phase of 6.0g is pressed into the oil phase through a hydrophobic microporous membrane with a uniform pore size under a certain pressure to obtain a W / O type emulsion; GST is slowly added dropwise in the resulting emulsion for cross-linking (amino and aldehyde groups) The molar ratio is 1: 1), and the crosslinking is carried out at normal tempe...

Embodiment 2

[0041] The hydrophobic membranes with pore diameters of 4.7 μm, 5.7 μm, 13 μm, and 19.6 μm were soaked in lipophilic substances, so that the porous membranes were fully wet to ensure that the hydrophobic chains on the membranes were completely stretched. Prepare 1wt% acetic acid aqueous solution, add a certain amount of NaCl and make it dissolve under stirring, its concentration is 1wt%, then add a certain amount of chitosan to make its concentration 1.5wt%, after it is completely dissolved, the solution Filter and set aside. Add the oil-soluble emulsifier to 60 ml of the mixed oil phase of liquid paraffin and petroleum ether, and stir until completely dissolved to form the oil phase. 6.0g of the water phase was pressed into the oil phase through various hydrophobic microporous membranes with uniform pore size under a certain pressure to obtain a W / O emulsion; in the obtained emulsion, GST was slowly added dropwise for cross-linking (amino and The mol ratio of aldehyde group ...

Embodiment 3

[0043] The hydrophobic membrane with a pore size of 4.7 μm is immersed in a lipophilic substance to fully wet the porous membrane to ensure that the hydrophobic chains on the membrane are completely stretched. Prepare 1wt% acetic acid aqueous solution, add a certain amount of NaCl and make it dissolve under stirring, its concentration is 1wt%, then add a certain amount of chitosan to make its concentration respectively 1.0wt%, 1.5wt% and 2.0wt% , after it was completely dissolved, the solution was filtered for later use. Add the oil-soluble emulsifier to 60 ml of the mixed oil phase of liquid paraffin and petroleum ether, and stir until completely dissolved to form the oil phase. The water phase of 6.0g is pressed into the oil phase through a hydrophobic microporous membrane with a uniform pore size under a certain pressure to obtain a W / O type emulsion; GST is slowly added dropwise in the resulting emulsion for cross-linking (amino and aldehyde groups) The molar ratio is 1: ...

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Abstract

Said invention provides equality size and stable dispersion chitosan microsphere and microcapsule medicine carrier to protein, polypeptide, anticancer agent, hormone etc hydrophilicity medicine and oil soluble medicine for releasing control and targeting administration. The characteristics are that, 1, equality size and stable dispersion chitosan microsphere and microcapsule medicine carrier is made by dissolving hydrophilicity medicine in aqueous solution of acetic acid, pressuring said water phase into oil phase through microporous membrane to get equality size emulsion drop, 2, dissolving oil soluble medicine in oil solvent and hydrophilicity medicine in aqueous solution of acetic acid, preparing O#-[1] / W colostrum by homogeneous phase emulsifier, pressuring it into oil phase through microporous membrane to obtain equality size composite emulsion drop, solidifying it to obtain equality size and stable dispersion chitosan microsphere and microcapsule medicine carrie. Under optimized condition, the diameter distribution coefficient of microsphere and microcapsule are controlled within 11 % , the diameter are controlled freely in 1-100 micrometer.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations of medical engineering Background technique [0002] Chitosan is a polysaccharide composed of glucosamine and N-acetylglucosamine copolymer, which is the product of deacetylation of chitin. Chitosan can be dissolved in dilute acid solution due to the free amino group on the molecular chain, so It has a wider range of uses than chitin. As a cationic biopolymer, chitosan has bioadhesion, biocompatibility and biodegradability, and its degradation products are non-toxic, non-immunogenic and non-carcinogenic. These unique properties of chitosan properties make it a biomedical carrier with broad application prospects [1][2][3] . [0003] As a biomedical carrier, chitosan is mainly used in the form of microspheres or microcapsules. For example, chitosan microspheres can be used as a separation medium for proteins and immobilization of enzymes. Because there are both hydroxyl groups and amino...

Claims

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Application Information

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IPC IPC(8): A61J3/07A61K9/50B01J13/02
Inventor 马光辉苏志国王连艳
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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