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Orally disintegrating tablet of 'Huoxiang Zhengqi' and its preparation process

An oral disintegrating tablet and Huoxiangzhengqi technology, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc. Good effect, rapid onset, rapid disintegration effect

Inactive Publication Date: 2005-03-16
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The dosage forms of Huoxiangzhengqi preparation in clinical application include oral liquid, water, soft capsule, capsule, tablet, pill, and drop pill. In the process of clinical application, it has a good effect on relieving heat stroke symptoms. A Huoxiangzhengqi preparation with rapid onset and better pharmacological effects has very broad social significance; no patent information about Huoxiangzhengqi orally disintegrating tablets has been retrieved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] (1) bulk drug of the present invention is:

[0125] 150 grams of atractylodes, 150 grams of tangerine peel, 150 grams of Magnolia officinalis (made from ginger), 250 grams of Angelica dahurica, 250 grams of Poria cocos, 250 grams of Dabupi, 150 grams of raw pinellia, 20 grams of licorice extract, 1.5ml of patchouli oil, purple Perilla oil 0.8ml;

[0126] (2) Take Angelica dahurica, pulverize it, put it into an ultrasonic extraction tank, extract it twice with 3 times, 95% ethanol, each time for 8 minutes, filter, combine the extracts, recover the ethanol to the utmost, concentrate in vacuum, and dry at low temperature. Obtain 1.6 grams of the effective part of Angelica dahurica;

[0127] (3) Get Magnolia Bark, extract 2 times with 6, 60% ethanol, each time for 2 hours, filter, extract the residue for later use, combine the extracts, recycle the ethanol to the utmost, concentrate, dry, and obtain the effective fraction of Magnolia Bark Alcohol Extraction 1.5 gram;

[...

Embodiment 2

[0134] (1) bulk drug of the present invention is:

[0135] 250 grams of atractylodes, 250 grams of tangerine peel, 250 grams of Magnolia officinalis (made from ginger), 350 grams of Angelica dahurica, 350 grams of Poria cocos, 350 grams of Dabupi, 250 grams of raw pinellia, 30 grams of licorice extract, 2.5ml of patchouli oil, purple Perilla oil 1.5ml;

[0136] (2) Take Angelica dahurica, pulverize it, put it into an ultrasonic extraction tank, extract it 4 times with 5 times, 95% ethanol, each time for 12 minutes, filter, combine the extracts, reclaim the ethanol to the utmost, concentrate in vacuum, and dry at low temperature. Obtain 4.5 grams of the effective part of Angelica dahurica;

[0137] (3) Take Magnolia officinalis, extract 2 times with 8 times, 80% ethanol, each time for 2 hours, filter, extract the residue for later use, combine the extracts, recover ethanol to the utmost, concentrate, dry, and obtain the active part of Magnolia officinalis 5 grams;

[0138] (...

Embodiment 3

[0144] (1) bulk drug of the present invention is:

[0145] 200 grams of atractylodes, 200 grams of tangerine peel, 200 grams of Magnolia officinalis (made from ginger), 300 grams of Angelica dahurica, 300 grams of poria cocos, 300 grams of big belly skin; 200 grams of raw pinellia, 25 grams of licorice extract, 2ml of patchouli oil, perilla Leaf oil 1ml;

[0146](2) Take Angelica dahurica, pulverize it, put it into an ultrasonic extraction tank, extract 3 times with 4 times, 95% ethanol, each time for 9 minutes, filter, combine the extracts, reclaim the ethanol to the utmost, concentrate in vacuum, and dry at low temperature. Obtain 3.6 grams of the effective part of Angelica dahurica;

[0147] (3) Take Magnolia officinalis, extract 2 times with 7 times, 65% ethanol, each time for 2 hours, filter, extract the residue for later use, combine the extracts, recover ethanol to the utmost, concentrate, dry, and obtain the active part of Magnolia officinalis 4.2 grams;

[0148] (4...

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PUM

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Abstract

Disclosed is an orally disintegrating tablet of 'Huoxiang Zhengqi' and its preparation process, characterized in that the tablet comprises the significant portions extracted from traditional Chinese medicinal atractylodes rhizome, dried orange peel, magnolia bark, dahurian angelica root, poria cocos wolf, areca catecha, pinellia tuber, extract of liquorice, patchouli oil, sweet basil oil and other medical use findings, the invention is also characterized that composite disintegrating tablet containing tetrahydroxy butane is employed, wherein the composite disintegrating tablet is obtained by combining tetrahydroxy butane with low substituted Hydroxypropylmethyl cellulose or sodium carboxymethylstarch or crossbond sodium carboxymethylstarch or insoluble cross bond polyvinylpyrrolidone by a finite proportion, the tetrahydroxy butane has the action of taste rectifying agent, thus reducing the consumption of medicinal findings in the preparation. Pharmacological experiment has shown that the disintegrating tablet has the advantages of quick disintegration, fast effect, and better pharmacological actions.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Huoxiang Zhengqi orally disintegrating tablet and a preparation method thereof. Background technique [0002] Orally disintegrating tablets are a new pharmaceutical preparation, which can be absorbed through the sublingual mucosa and directly enter the blood, effectively avoiding the first-pass effect, so the dosage is small, safe and has a rapid effect. Although it is an oral preparation, it can achieve the effect of an injection preparation. Therefore, it is gradually becoming a hot spot in the field of pharmaceutical companies and research and development. The dosage form is mainly to select a suitable fast disintegrating agent, and the tablet made of it has a certain hardness and a certain degree of porosity. When taking it, it does not need water to assist swallowing, and it can quickly disintegrate into fine particles in the mou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P1/12A61P43/00
Inventor 张晴龙
Owner 张晴龙
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