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Freeze dried powder injection of red peony root and safflower for treating cardiovascular and cerebrovascular disease and its preparation method

A technique for cardiovascular and cerebrovascular diseases and freeze-dried powder injection, which is applied in the field of freeze-dried powder for injection and its preparation, can solve problems such as application that have not been reported, and achieve the effects of high content of active ingredients, improved clarity and improved quality

Inactive Publication Date: 2005-01-26
北京神农坛医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the combination of the two is applied to the treatment of clinical cardiovascular and cerebrovascular diseases, especially the application of clinical injection preparations has not been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Prescription Radix Paeoniae Rubra 1000g Safflower 1000g

[0045] The above two flavors, Radix Paeoniae Rubra, are crushed into coarse powder, together with safflower, decocted and extracted three times, the extracts are combined, filtered, high-speed centrifuged, and the centrifuged liquid is added to the processed AB-8 macroporous adsorption resin column , first use 2 times the amount of deionized water to elute, then use 3 times the amount of 30% ethanol solution to elute, collect the 30% ethanol eluate, recover the ethanol under reduced pressure until there is no alcohol smell, continue to concentrate to 1ml The liquid medicine is equivalent to 1g of the crude drug.

[0046] 2. Take the above-mentioned medicinal liquid, ultrafilter it with a hollow fiber column with a molecular weight cut-off of 3000, add deionized water to the ultrafiltration concentrated solution and repeat the ultrafiltration 3 times, collect the ultrafiltration permeate, concentrate at low tempe...

Embodiment 2

[0049] Prescription Radix Paeoniae Rubra 1000g Safflower 500g

[0050] The above two flavors, Radix Paeoniae Rubra, are crushed into coarse powder, together with safflower, decocted and extracted three times, the extracts are combined, filtered, high-speed centrifuged, and the centrifuged liquid is added to the processed AB-8 macroporous adsorption resin column , first use 2 times the amount of deionized water to elute, then use 3 times the amount of 30% ethanol solution to elute, collect the 30% ethanol eluate, recover the ethanol under reduced pressure until there is no alcohol smell, continue to concentrate to 1ml The liquid medicine is equivalent to 1g of the crude drug.

[0051] 2. Take the above-mentioned medicinal liquid, ultrafilter it with a hollow fiber column with a molecular weight cut-off of 3000, add deionized water to the ultrafiltration concentrated solution and repeat the ultrafiltration 3 times, collect the ultrafiltration permeate, concentrate at low tempera...

Embodiment 3

[0054] Prescription Radix Paeoniae Rubra 1000g Safflower 500g

[0055] The above two flavors, Radix Paeoniae Rubra, are crushed into coarse powder, together with safflower, decocted and extracted three times, the extracts are combined, filtered, and centrifuged at high speed, and the centrifugate is added to the D101 macroporous adsorption resin column that has been treated. Elute with 3 times the column volume of deionized water, then elute with 40% ethanol solution of 4 times the column volume, collect the 40% ethanol eluate, and recover the ethanol under reduced pressure until every 1ml of the drug solution is equivalent to the crude drug 1g.

[0056] 2. Take the above-mentioned medicinal liquid, ultrafilter it with a hollow fiber column with a molecular weight cut-off of 3000, add deionized water to the ultrafiltration concentrated solution and repeat the ultrafiltration 3 times, collect the ultrafiltration permeate, concentrate at low temperature to dryness, and obtain Ra...

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Abstract

In accordance with the invention, water extraction method is employed to extract the effective components of safflower and radix paeoniae rubrathe, big porous resin adsorption method is employed for purification and refining.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and specifically relates to a freeze-dried powder injection composed of effective parts of traditional Chinese medicine Paeoniae Rubra and safflower for treating cardiovascular diseases and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases are clinically common and frequently-occurring diseases. In recent years, with the improvement of people's living standards and the aging of the population structure, the incidence rate has been increasing year by year. Drugs for the treatment of cardiovascular and cerebrovascular diseases have been developed. gradually become a research hotspot. More and more clinical reports have shown that traditional Chinese medicine has a good application prospect in the treatment of cardiovascular and cerebrovascular diseases, especially Chinese medicine has few side effects, and is increasingly pop...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61P9/00A61P9/10
Inventor 张平
Owner 北京神农坛医药科技有限公司
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