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Porous solid material for adsorbing and inactivating virus and application thereof

A technology of porous solids and viruses, applied in chemistry and other directions, to achieve the effect of low self-toxicity, wide range and low cost

Inactive Publication Date: 2004-12-08
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If solid porous materials can be used for adsorption and inactivation of viruses, it will play a very active role in the prevention and treatment of viral diseases, but there are no relevant reports at home and abroad so far

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The porous solid material of the present invention can be prepared by methods such as precipitation, co-precipitation, sol-gel, impregnation, hydrothermal synthesis, etc., but is not limited by the methods listed above. The present embodiment adopts sol-gel method; Specifically:

[0016] 78.4g ZrOCl 2 ·H 2 O was dissolved in 150ml of deionized water, then slowly added to 688g of silica sol, after stirring evenly, NH 3 ·H 2 From 0 to pH ≈ 7, the solid was centrifuged, washed, dried at 110°C, and roasted at 550°C for 2 hours to obtain a sample. Measured by Nova 4000 adsorption instrument, the average pore diameter is 90nm, and the pore volume is 0.35ml / g.

Embodiment 2-14

[0018] Porous solid materials with different pore structures and pore volumes and different meso-oxide compositions were prepared by various methods. Then, the Nova 4000 adsorption instrument was used for determination, and the results are listed in Table 1.

[0019] implement

Embodiment 15

[0021] The DNA molecule is selected as a 211bp DNA fragment in the first exon of the K-ras gene, which is amplified by PCR with fluorescent (6-FAM) labeled primers. The PCR product was diluted with deionized water into a 30-fold stock solution of DNA molecules. Then weigh 0.2-0.3 g of the porous solid material prepared in Example 2, and spread it evenly on a watch glass. Spray 50 μl of the DNA molecular stock solution on the surface of the catalytic material, and mix thoroughly, and then wash it with water for 10 minutes and 20 minutes, and then centrifugally filter. The supernatant is electrophoresed on a 310-type DNA automatic genetic analyzer, and analyzed by laser-induced fluorescence detection. . After 10 minutes of adsorption, there is no DNA molecule in the eluate, indicating that the porous solid material can completely absorb DNA within 10 minutes, and it cannot be washed away by water after adsorption.

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Abstract

A porous solid material for adsorbing and deactivating the viruses, especially the parainfluenza virus, is prepared from one of TiO2, ZrO2, SiO2 and Al2O3 or P2O5 or their mixture. It can be modified by one or more elements in the families VIII, Ib, IIb, or IIa.

Description

technical field [0001] The invention relates to the prevention and treatment technology of viral diseases, in particular to a porous solid material for absorbing and inactivating viruses and its application. Background technique [0002] Viruses are one of the important pathogenic factors of human beings. The prevention and treatment of many viral diseases (such as AIDS, atypical pneumonia, etc.) make modern society face major challenges. Effective virus inactivation is an important means to prevent the spread of infectious viral diseases. [0003] Activated carbon or modified activated carbon is often used to kill bacteria during water treatment. Ag-containing nanoporous solid materials have been widely used as fungicides in the past. Such as Japanese patents JP 62241932 (1987), JP 03161275 (1991), JP 03215527 (1991) and JP 07033906 (1995) all adopt Ag, Cu or Zn exchanged A-type zeolite as deodorant and bactericide for food packaging, etc. field. U.S. Patent No. 6,544,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/16
Inventor 刘中民许磊齐越许国旺杨凌张卓然马磊郑丛龙明平文陈严张涛黄向阳包信和
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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