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Medicine for treating coronary heart disease and angina pectoris and its pharmacologic effect

The technology of a kind of medicinal material, Salvia miltiorrhiza, is applied in the field of drugs for the treatment of coronary heart disease and angina pectoris, which can solve the problems of high industrial production cost, hinder industrial production, and complicated process, and achieve the effect of low cost, less impurities, and simple process equipment

Inactive Publication Date: 2004-11-24
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One of the common defects of the above methods is that the water extract must be concentrated. Since the stability of the water-soluble parts of Salvia miltiorrhiza has a lot to do with the temperature and the length of the treatment time, etc., the method of concentrating under reduced pressure is generally adopted, but Good decompression concentration equipment is relatively expensive. For example, repeated decompression concentration in the process will complicate the process, resulting in high industrial production costs, which seriously hinders the realization of its industrial production
Another defect is that productive rate is lower, is generally 2~3%, and low productive rate has also limited the application of these methods in industry

Method used

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  • Medicine for treating coronary heart disease and angina pectoris and its pharmacologic effect
  • Medicine for treating coronary heart disease and angina pectoris and its pharmacologic effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] 500 g of Salvia miltiorrhiza was crushed into coarse powder, and deionized water was added to heat and extract twice at 100° C. in a slightly boiling state. Add 6 times the amount of water for the first time and heat for 1 hour; add 4 times the amount of water for the second time and heat for 1 hour respectively. Combine the extracts with 10% hydrochloric acid to adjust the pH value to 1, filter, collect the filtrate, apply macroporous adsorption resin (D101 type), wash with deionized water until neutral, continue to elute with 80% methanol, and wait until the color band Come down and collect this ribbon. Concentrate under reduced pressure at 55°C to form a dry powder to obtain 24.05 g of the water-soluble effective fraction of Danshen, and the yield of the finished product is 4.80% of the crude drug amount. Measured by the method of the patent application literature (Chinese patent, application number 01142288.2, application date September 2001), the finished product ...

Embodiment 2

[0060] 500 g of Salvia miltiorrhiza was crushed into a coarse powder, and deionized water was added to heat and extract twice at 80°C. For the first time, add 7 times the amount of water and heat for 2 hours; add 5 times the amount of water for the second time and heat for 1.5 hours respectively. After adjusting the pH value of the extract to 2 with 10% hydrochloric acid, filter it, collect the macroporous adsorption resin (D101 type) on the filtrate, wash it with deionized water until it is neutral, continue to elute with 70% ethanol, and wait until the color band comes off. Collect this ribbon. Concentrate under reduced pressure at 50°C to form a dry powder to obtain 23.75 g of the water-soluble effective fraction of Salvia miltiorrhiza, and the yield of the finished product is 4.75% of the crude drug amount. Measured by the method of the patent application literature (Chinese patent, application number 01142288.2, application date September 2001), the finished product cont...

Embodiment 3

[0062] 500 g of Salvia miltiorrhiza was crushed into coarse powder, and deionized water was added to heat and extract twice at 100° C. in a slightly boiling state. Add 8 times the amount of water for the first time and heat for 3 hours; add 6 times the amount of water for the second time and heat for 2 hours respectively. After adjusting the pH value of the extract to 3 with 10% sulfuric acid, filter, collect the macroporous adsorption resin (AB-8 type) on the filtrate, wash with deionized water until neutral, continue to elute with 60% propanol, and wait for the color Take it down and collect this ribbon. Concentrate under reduced pressure at 45°C to form a dry powder to obtain 22.95 g of the water-soluble effective fraction of Danshen, and the yield of the finished product is 4.59% of the crude drug amount. Measured by the method of patent application literature (Chinese patent, application number 01142288.2, application date September 2001), the finished product contains 7...

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Abstract

The medicine for treating coronary heart disease and angina pectoris is prepared with red sage as main material, and through water extraction, regulating pH value with acid, filtering, adsorption in macroporous resin, lower alcohol elution and low temperature concentration into dry powder. The pharmacological effect of the Chinese medicine is also disclosed.

Description

technical field [0001] The invention relates to a medicine for treating angina pectoris of coronary heart disease, in particular to a preparation made from Chinese herbal medicine through a specific process, and the invention also discloses its pharmacological action. Background technique [0002] Coronary heart disease angina pectoris refers to angina pectoris caused by myocardial ischemia and hypoxia due to coronary artery sclerosis or spasm, accounting for about 90% of angina pectoris patients. At present, the methods of Western medicine for treating angina pectoris mainly focus on dilating blood vessels, reducing blood viscosity, anti-platelet aggregation, and anti-coagulation. The drugs used are nitrates, nitrites, β-receptor blockers, calcium antagonists, thrombolytics, etc., but due to their large toxic and side effects, it is not suitable for long-term use, and most drugs are aimed at symptomatic Treatment has no significant effect o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P7/02A61P9/10
Inventor 张文生黄芝娟李德坤岳洪水魏峰
Owner TIANJIN TASLY PHARMA CO LTD
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