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Panaxitriol saponin preparation with biological activity and use

A ginseng diol saponin, bioactive technology, applied in the direction of organic active ingredients, medical preparations containing active ingredients, applications, etc., can solve the problem of ginsenoside damage, improve hemodynamics, improve sleep time and Effects of sleep quality and product quality that are easy to control

Inactive Publication Date: 2004-09-29
昆明杉榆生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that the ginsenosides that are easy to be hydrolyzed will be destroyed by strong alkali.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 1. Take 100 grams of ginsenosides, dissolve in 500 ml of 90% ethanol and stir;

[0057] 2. Add 2000 ml of acetone while stirring, and after fully stirring, set it at 5°C for more than 8 hours, filter the filtrate, and concentrate to dryness under reduced pressure;

[0058] 3. Put the above-mentioned dried filtrate on the silica gel column, and use CHCl 3 :CH 3 OH=7:3 solvent elution, collect 5000 milliliters of the eluate containing panaxatriol saponin, concentrate and dry to obtain Rg 1 More than 45% panaxatriol saponins 10 grams;

[0059] 4, the above-mentioned ginseng triol saponins are subjected to silica gel column chromatography, and CHCl 3 :CH 3 OH=7:3 solvent elution, collect Rg 1 The components are repeated several times to obtain a finished product of panaxatriol saponin with a content of more than 90%.

Embodiment 2

[0061] 1. Take 100 grams of ginsenosides, dissolve in 700 ml of 70% ethanol and stir;

[0062] 2. Add 3000 ml of acetone while stirring, and after stirring thoroughly, set it at 15°C for more than 8 hours, filter the filtrate, and concentrate to dryness under reduced pressure;

[0063] 3. Put the above-mentioned dried filtrate on the silica gel column, and use CHCl 3 :CH 3 OH=7:3 solvent elution, collect 1000 milliliters of the eluate containing panaxatriol saponin, concentrate and dry to obtain Rg 1 Greater than 45% Panaxatriol Saponins 10g:

[0064] 4, the above-mentioned ginseng triol saponins are subjected to silica gel column chromatography, and CHCl 3 :CH 3 OH=7:3 solvent elution, collect Rg 1 The components are repeated several times to obtain a finished product of panaxatriol saponin with a content of more than 90%.

Embodiment 3

[0066] Get material by following formula, adopt existing process method to make 1000 bags of ginseng triol saponin granule granule, every bag weighs 3.5g:

[0067] Panaxatriol saponins (Rg 1 =45%) 125g

[0068] 3000g cane sugar

[0069] Dextrin 400g

[0070] Alcohol in moderation.

[0071] Take once a day, one bag each time (before going to bed).

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PUM

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Abstract

Panaxitriol saponin is prepared into food product or medicine preparation capable of strengthening positively the activity of cerebral cell and cerebral nerve cell, treating and improving insufficient cerebral blood and oxygen supply, weakened nerve activity disease and malfunction caused by weakened blood system or nerve system; improving haemodynamic and blood quality; preventing inflammation of blood vessel and nerve; raising oxygen pressure in blood; and improving sleep quality.

Description

technical field [0001] The invention relates to a bioactive preparation, especially a preparation containing panaxatriol saponin and its application in the field of pharmacy. Background technique [0002] The roots, leaves and flowers of Araliaceae Panax genus—Ginseng (also known as Korean ginseng), American ginseng, Panax notoginseng (or Tianqi), etc. have medicinal value. Ginsenosides, American ginsenosides and three Seven total saponins mainly contain Rb 1 Mainly panaxadiol saponins and Rg 1 Mainly panaxatriol-type saponins. Panaxadiol-type saponins and panaxatriol-type saponins have very similar effects in improving the hemodynamics of blood circulation, reducing blood viscosity, reducing blood lipids, etc., as disclosed in Chinese patent ZL89100070. And its pharmaceutical composition and application", wherein, the preparation method is to dissolve said total saponins in a lower alcohol solution, and then use alkali metal hydroxide as a precipitating agent to carry ou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A61K31/7048A61P9/10A61P25/00C07J17/00
Inventor 艾黎
Owner 昆明杉榆生物技术有限公司
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